• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current opinion in gastroenterology >Nutrient absorption.
【24h】

Nutrient absorption.

机译：营养吸收。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Some interesting advances in mechanisms and regulation of nutrient absorption were reported last year. Further evidence was obtained that the rate-limiting step in triacylglycerol absorption, especially with large doses of lipid, is transport of prechylomicrons from the endoplasmic reticulum to the Golgi apparatus. Targeted disruption of the adenosine triphosphate-binding cassette transporter in mice produced changes similar to human Tangier disease and suggested that this mouse may be a model for studying intestinal high-density lipoprotein assembly and secretion. A new mechanism for carbohydrate malabsorption was discovered: in sucrase-isomaltase deficiency, the enzyme fails to anchor in the brush border membrane and so is secreted into the lumen, where it is ineffective. Glycosylating insulin at B1 phenylalanine permitted it to bind to the brush border membrane and greatly enhanced its hypoglycemic activity when given orally. CaCo-2 cells and normal human enterocytes were shown to have two variants of the human sodium-dependent vitamin C transporter, hSVCT1; one is active and the other is an inactive splice variant. In rats, the divalent metal ion transporter, DMT1, appeared to be important for regulation of both absorption of iron and its movement into the liver.
机译：去年报道了一些机制和营养吸收调节方面的有趣进展。获得了进一步的证据，尤其是使用大剂量脂质时，三酰基甘油吸收的限速步骤是将乳糜微粒从内质网运输到高尔基体。小鼠三磷酸腺苷结合盒转运蛋白的靶向破坏产生了类似于人类丹吉尔病的变化，并暗示该小鼠可能是研究肠道高密度脂蛋白组装和分泌的模型。发现了碳水化合物吸收不良的新机制：在蔗糖酶-异麦芽糖酶缺乏症中，该酶无法锚定在刷状缘膜上，因此被分泌到管腔中，无效。口服时，B1苯丙氨酸的糖基化胰岛素使其能够与刷状缘膜结合，并大大增强其降血糖活性。 CaCo-2细胞和正常人肠上皮细胞被证明具有人类钠依赖性维生素C转运蛋白hSVCT1的两个变体。一个是活动的，另一个是非活动的剪接变体。在大鼠中，二价金属离子转运蛋白DMT1对于调节铁的吸收及其向肝中的移动的调节似乎很重要。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号