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首页> 外文期刊>Current opinion in gastroenterology >Fecal microbiota transplantation: Past, present and future
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Fecal microbiota transplantation: Past, present and future

机译：粪便微生物群移植：过去，现在和未来

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PURPOSE OF REVIEW: Fecal microbiota transplantation (FMT) re-establishes a balanced intestinal flora with resultant cure of recurrent Clostridium difficile infection (RCDI). FMT has also been used to treat other gastrointestinal (GI) diseases including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and chronic constipation and a variety of non-GI disorders. The purpose of this review is to discuss the intestinal microbiota and FMT treatment of GI and non-GI diseases. RECENT FINDINGS: It is known that an imbalanced intestinal microbiota predisposes to CDI, IBD and IBS. The complex role of intestinal microbiota to maintain health, however, is a newer concept that is being increasingly studied. The microbiome plays an important role in cellular immunity and energy metabolism and has been implicated in the pathogenesis of non-GI autoimmune diseases, chronic fatigue syndrome, obesity and even some neuropsychiatric disorders. SUMMARY: FMT is a highly effective cure for RCDI, but increased knowledge of the intestinal microbiota in health maintenance, as well as controlled trials of FMT in a wide range of disorders are needed before FMT can be accepted and applied clinically.
机译：审查目的：粪便菌群移植（FMT）可重新建立平衡的肠道菌群，从而治愈复发的艰难梭菌感染（RCDI）。 FMT也已用于治疗其他胃肠道（GI）疾病，包括炎症性肠病（IBD），肠易激综合症（IBS），慢性便秘和多种非胃肠道疾病。这篇综述的目的是讨论肠道菌群和胃肠道疾病对胃肠道和非胃肠道疾病的治疗。最近的发现：众所周知，肠道菌群失衡易导致CDI，IBD和IBS。肠道菌群维持健康的复杂作用是一个新概念，正在被越来越多的研究。微生物组在细胞免疫和能量代谢中起着重要作用，并与非胃肠道自身免疫性疾病，慢性疲劳综合征，肥胖症甚至某些神经精神疾病的发病机理有关。简介：FMT是一种用于RCDI的高效治疗方法，但是在FMT可以被临床接受和应用之前，需要增加对肠道菌群健康维护的了解以及FMT在多种疾病中的对照试验。

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