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首页> 外文期刊>Current opinion in lipidology >Fatty acid transport proteins.
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Fatty acid transport proteins.

机译：脂肪酸转运蛋白。

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PURPOSE OF REVIEW: Fatty acid transport proteins are a family of proteins involved in fatty acid uptake and activation. This review summarizes recent progress in elucidating the function of fatty acid transport proteins. RECENT FINDINGS: Recent experiments clearly establish FATP1 as a regulated fatty acid transporter in both adipose tissue and muscle with important roles in energy homeostasis, thermogenesis and insulin resistance. Knockout of FATP5 in mice show it to be a bifunctional protein required for both hepatic fatty acid uptake and bile acid reconjugation. The most striking phenotype of FATP4 deletion is a defect in skin homeostasis, which may be due to its very long chain acyl-coenzyme A synthetase activity. Fatty acid transport proteins are increasingly being recognized as multifunctional proteins that can mediate the uptake of fatty acids as well as catalyze the formation of coenzyme A derivatives using long-chain and very-long chain fatty acids, bile acids and bile acid precursors as substrates. SUMMARY: Modulation of fatty acid transport protein function can result in altered energy homeostasis and insulin sensitivity, defective skin homeostasis, and altered bile acid metabolism. Both fatty acid uptake and enzymatic activity of fatty acid transport proteins likely contribute to these phenotypes. Future studies are needed to better understand the molecular mechanism of fatty acid transport protein function and the physiological role of FATP2, FATP3, and FATP6.
机译：审查目的：脂肪酸转运蛋白是涉及脂肪酸吸收和活化的蛋白质家族。这篇综述总结了阐明脂肪酸转运蛋白功能的最新进展。最近的发现：最近的实验清楚地证明FATP1是脂肪组织和肌肉中受调节的脂肪酸转运蛋白，在能量稳态，生热和胰岛素抵抗中具有重要作用。小鼠中FATP5的敲除表明它是肝脂肪酸摄取和胆汁酸重新结合所必需的双功能蛋白。 FATP4缺失的最明显表型是皮肤稳态中的缺陷，这可能是由于其很长的酰基辅酶A合成酶活性所致。脂肪酸转运蛋白越来越多地被认为是多功能蛋白，它可以介导脂肪酸的摄取以及使用长链和超长链脂肪酸，胆汁酸和胆汁酸前体作为底物来催化辅酶A衍生物的形成。摘要：脂肪酸转运蛋白功能的调节可导致能量动态平衡和胰岛素敏感性改变，皮肤动态平衡不良以及胆汁酸代谢改变。脂肪酸摄取和脂肪酸转运蛋白的酶促活性都可能有助于这些表型。需要进一步的研究来更好地了解脂肪酸转运蛋白功能的分子机制以及FATP2，FATP3和FATP6的生理作用。

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