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Enteroaggregative Escherichia coli pathogenesis

机译：肠聚合性大肠杆菌的发病机理

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Identification of AggR or members of the AggR regulon may identify pathogenic EAEC strains, called typical EAEC. Epidemiotogic and clinical investigations in many settings should now include detection of typical EAEC,Enteroaggregative Escherichia coli (EAEC) is a pathotype of diarrheagenic E. coli defined by its characteristic aggregative, or stacked brick, pattern of adherence to HEp-2 epithelial cells in culture. The first association of EAEC with diarrheal disease was published in 1987, a prospective study of pediatric diarrhea in Chile [1]. Since that time, EAEC has emerged as an important pathogen in several clinical scenarios, including traveler's diarrhea [2], endemic pediatric diarrhea among children in resource-poor [3] and resource-rich [4"] countries, and persistent diarrhea among HIV-infected patients [5]. Aspects of the pathogenesis of EAEC infection are becoming clear. Here, we review the most recent contributions to our understanding of this emerging pathogen.
机译：AggR或AggR调节子成员的鉴定可以鉴定出致病性EAEC菌株，称为典型EAEC。如今在许多情况下的流行病学和临床研究应包括检测典型的EAEC，肠聚合性大肠杆菌（EAEC）是腹泻性大肠杆菌的病原体，其特征在于其对培养的HEp-2上皮细胞粘附的特征性聚集或堆积砖。 EAEC与腹泻疾病的首次关联发表于1987年，这是智利对小儿腹泻的一项前瞻性研究[1]。从那时起，EAEC在几种临床情况中已成为重要的病原体，包括旅行者的腹泻[2]，资源匮乏的[3]和资源丰富的[4“]国家的儿童中的地方性小儿腹泻以及艾滋病毒中的持续性腹泻感染的患者[5]。EAEC感染的发病机制已变得清晰，在这里，我们回顾了对我们对这种新兴病原体的了解的最新贡献。

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