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首页> 外文期刊>Current opinion in gastroenterology >Recent findings in the cell and molecular biology of the small intestine.
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Recent findings in the cell and molecular biology of the small intestine.

机译：小肠细胞和分子生物学的最新发现。

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PURPOSE OF REVIEW: Recently published research exploring new aspects of the molecular and cell biology of the small intestine is reviewed. RECENT FINDINGS: The importance has become apparent of several paracrine and autocrine signaling pathways that regulate stem cell proliferation in the crypts and differentiation on the villus. These growth factor systems include: the Wnt pathway, with molecules such as Dickkopf, APC, beta-catenin and SOX9; the Hedgehog system; and members of the TGF-beta family such as bone morphogenetic proteins. Transcription factors activating the expression of genes in the intestine include CDX1, CDX2 and HNF1alpha and their actions are increasingly well characterized. Important findings are being made relating to the Toll-like receptors, which have a major role in innate immunity and intestinal homeostasis. SUMMARY: Many new discoveries using increasingly sophisticated techniques have demonstrated the complexity of the cellular and molecular interactions in the intestinal mucosa.
机译：审查的目的：审查了最近发表的探索小肠分子和细胞生物学新方面的研究。最近的发现：在调节隐窝中的干细胞增殖和在绒毛上分化的几种旁分泌和自分泌信号通路的重要性已经变得显而易见。这些生长因子系统包括：Wnt途径，带有Dickkopf，APC，β-catenin和SOX9等分子;刺猬系统;和TGF-beta家族的成员，例如骨形态发生蛋白。激活肠中基因表达的转录因子包括CDX1，CDX2和HNF1alpha，它们的作用日益得到很好的表征。与Toll样受体有关的重要发现正在发生，其在先天免疫和肠道动态平衡中起主要作用。摘要：使用日益复杂的技术的许多新发现已证明肠粘膜中细胞和分子相互作用的复杂性。

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