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首页> 外文期刊>Current opinion in gastroenterology >Chronic pancreatitis.
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Chronic pancreatitis.

机译：慢性胰腺炎。

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PURPOSE OF REVIEW: Clinicians are learning more about chronic pancreatitis but are entering an era of some confusion, primarily driven by uncovering new etiologies of chronic pancreatitis. Ideally, this knowledge will lead to better diagnosis and treatment, and abandonment of ill-conceived treatments. In contrast with previous reviews, this review highlights select contributions this year that may develop into true advances in chronic pancreatitis. RECENT FINDINGS: Small steps have been made to understand better the molecular basis of chronic pancreatitis. Diagnosis of early chronic pancreatitis remains challenging. Rapid diagnosis by combining endoscopy and a direct stimulatory test of pancreatic function may lead to more widespread use of function testing, but this test is not ready for clinical use. Application of microarray and proteomic technologies may aid future diagnosis of chronic pancreatitis. The failure to account clearly for the phenotype of patients with chronic pancreatitis may confound delineating the etiologies of chronic pancreatitis. Clinical description and studies of autoimmune pancreatitis have led to the realization that steroids are an effective treatment for this form of chronic pancreatitis. Genetic-based studies have provided insight into the pathogenic mechanisms of chronic pancreatitis. Investigation of the role of stellate cells, an essential component fibrogenesis, has led to identification of potential novel treatments for chronic pancreatitis. SUMMARY: Ongoing basic and clinical research this past year has characterized further the histologic, genetic, molecular, and clinical aspects of chronic pancreatitis, efforts that may translate into novel therapies once well-designed, controlled studies have been performed.
机译：审查目的：临床医生正在学习更多有关慢性胰腺炎的知识，但正进入一个混乱的时代，这主要是由于发现了慢性胰腺炎的新病因。理想情况下，这种知识将导致更好的诊断和治疗，以及放弃治疗不当的治疗方法。与以前的综述相反，本综述重点介绍了今年可能会发展成为慢性胰腺炎真正进展的部分贡献。最近的发现：已经采取了一些小步骤来更好地了解慢性胰腺炎的分子基础。早期慢性胰腺炎的诊断仍然具有挑战性。通过结合内窥镜检查和直接刺激性胰腺功能检查来进行快速诊断可能会导致功能检查的更广泛使用，但是该检查尚未准备好用于临床。芯片技术和蛋白质组学技术的应用可能有助于慢性胰腺炎的进一步诊断。无法清楚地说明慢性胰腺炎患者的表型可能会混淆描述慢性胰腺炎的病因。自身免疫性胰腺炎的临床描述和研究已使人们认识到，类固醇可以有效治疗这种形式的慢性胰腺炎。基于遗传的研究提供了对慢性胰腺炎的致病机制的见解。对星状细胞（一种重要的纤维生成成分）的作用的研究已导致鉴定潜在的新型治疗慢性胰腺炎的方法。摘要：去年正在进行的基础和临床研究进一步表征了慢性胰腺炎的组织学，遗传，分子和临床方面，一旦进行了精心设计，对照的研究，可能会转化为新疗法。

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