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Small bowel infections

机译:小肠感染

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摘要

Infections of the human gastrointestinal tract with enteric pathogens are among the leading causes of disease, suffering, and death worldwide. Enteric pathogens are ingested from contaminated food and water and pass through the entire gastrointestinal tract during establishment in the host and subsequent shedding and spread to new hosts. Nonetheless, each pathogen exploits a unique niche within the intestinal tract and has developed unique strategies to interact with different host cells and functions. The most important and prevalent infections of the small intestine are caused by diarrheagenic Escherichia coli, particularly enterotoxigenic and enteropathogenic ?co//, rotavirus, Giardia lamblia, and Cryptosporidium parvum. This review focuses on recent insights into the pathogenesis of infections with these pathogens and host defenses against them.
机译:胃肠道病原体感染人胃肠道是世界范围内疾病,痛苦和死亡的主要原因。肠道病原体是从受污染的食物和水中摄取的,并在宿主体内建立过程中穿过整个胃肠道,随后脱落并传播到新的宿主中。尽管如此,每种病原体都在肠道内利用独特的生态位,并已开发出与不同宿主细胞和功能相互作用的独特策略。小肠最重要和最普遍的感染是由腹泻性大肠杆菌引起的,尤其是肠毒素和肠致病性大肠杆菌,轮状病毒,贾第鞭毛虫和小隐孢子虫。这篇综述集中在对这些病原体感染的发病机理以及针对它们的宿主防御的最新见解。

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