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首页> 外文期刊>Current opinion in hematology >Transfusion-related acute lung injury.
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Transfusion-related acute lung injury.

机译：与输血有关的急性肺损伤。

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摘要

Transfusion-related acute lung injury is a life-threatening complication of hemotherapy associated with the transfusion of plasma-containing blood products. It is characterized by acute respiratory distress, pulmonary edema and hypoxemia. Although its frequency is unknown, Food and Drug Administration data suggest that it is the third most common cause of transfusion-associated deaths, representing 9% of reported cases. Males and females of all ages are at equal risk. To date, there is no recognized profile of individuals who are at increased risk for this complication. Although there are two purported mechanisms of injury, the preponderance of evidence suggests that passively transfused complement-activating antibodies (either granulocyte or HLA-specific) act as mediators, which result in granulocyte aggregation, activation, and microvascular pulmonary injury. With appropriate respiratory intervention, most patients recover within 96 hours of the original insult and without permanent pulmonary sequelae.
机译：与输血有关的急性肺损伤是与含血浆血液制品输血相关的危及生命的血液疗法并发症。它的特征是急性呼吸窘迫，肺水肿和低氧血症。尽管其发生频率未知，但美国食品药品监督管理局的数据表明，它是与输血有关的死亡的第三大最常见原因，占报告病例的9％。所有年龄段的男性和女性都处于同等风险。迄今为止，尚无公认的个体并发症风险较高。尽管有两种据称的损伤机制，但大量证据表明，被动输注的补体激活抗体（粒细胞或HLA特异性抗体）起着介质的作用，导致粒细胞聚集，激活和微血管肺损伤。通过适当的呼吸干预，大多数患者可在最初的感染后96小时内康复，并且没有永久性的肺后遗症。

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