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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Friend or foe? Effect of oral resveratrol on cisplatin ototoxicity
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Friend or foe? Effect of oral resveratrol on cisplatin ototoxicity

机译：是敌是友？ 口服白藜芦醇对顺铂耳毒性的影响

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Objectives/Hypothesis Our objectives were to study effects of orally administered resveratrol (RV) against cisplatin (CDDP) ototoxicity in different doses and to investigate ultrastructural changes in the cochlea and brainstem. Study Design In vivo study using an animal model. Methods Thirty-two male Wistar albino rats were divided into six groups. Baseline distortion product otoacoustic emissions (DPOAEs) and auditory brainstem response (ABR) measurements were made. In groups I, II, and III, only saline, RV, and CDDP were given, respectively. Group IV, V, and VI animals were administered 10 mg/kg/day, 1 mg/kg/day, and 0.1 mg/kg/day of RV for 10 days, respectively, before 16 mg/kg CDDP injections were administered on day 11. All animals were sacrificed after repeated DPOAEs and ABR measurements were made on day 14. Cochleas of animals were investigated with transmission electron microscopy. Apoptosis were investigated with caspase-3 activity and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) method in the brainstem. Results In groups IV and V, DPOAEs and ABR findings revealed that oral administration of RV 10 mg/kg/day and 1 mg/kg/day doses before CDDP injection enhanced ototoxicity. In group VI, electomicroscopy revealed better ultrastructural findings than in the cisplatin group; however, these changes were not reflected in the audiological findings accordingly. Conclusions Our results implied that there were noticeable differences between different oral RV doses used for cisplatin ototoxicity. Especially in higher doses, RV was observed to enhance cisplatin ototoxicity.
机译：目的/假设我们的目标是研究口服施用的白藜芦醇（RV）对不同剂量的顺铂（CDDP）耳毒性的影响，并研究耳蜗和脑干的超微结构变化。用动物模型研究体内研究的研究。方法将三十二个雄性Wistar白化大鼠分为六组。对基线失真产品耳声发射（DPOAES）和听觉脑干响应（ABR）进行测量。在一组I，II和III中，仅给予盐水，RV和CDDP。在第一次施用16mg / kg CDDP注射之前，分别施用10mg / kg /天，1mg / kg /天，1mg / kg /天，0.1mg / kg /天，分别为0.1mg / kg /天的RV 10天11.在重复的DPOAE和ABR测量后，在第14天进行后处死所有动物。用透射电子显微镜检查动物的施用。通过在脑干中用Caspase-3活性和末端脱氧核苷酸转移酶介导的DUTP-BIOTIN切片末端标记（TUNEL）方法研究了细胞凋亡。结果IV组和V，DPOA和ABR发现表明，在CDDP注射之前，ORAL施用RV 10mg / kg /天和1mg / kg /天剂量增强的耳毒性。在VI组中，ElectoMicroscopy揭示了比顺铂组更好的超微结构结果;然而，这些变化并没有相应地反映在听力学调查结果中。结论我们的结果暗示，用于顺铂耳毒性的不同口服RV剂量之间存在明显的差异。特别是较高剂量，观察到RV以增强顺铂耳毒性。

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