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首页> 外文期刊>Current opinion in lipidology >Nutrigenomics and nutrigenetics.
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Nutrigenomics and nutrigenetics.

机译：营养基因组学和营养遗传学。

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PURPOSE OF REVIEW: Nutritional genomics has tremendous potential to change the future of dietary guidelines and personal recommendations. Nutritional genomics covers nutrigenomics, which explores the effects of nutrients on the genome, proteome and metabolome, and nutrigenetics, the major goal of which is to elucidate the effect of genetic variation on the interaction between diet and disease. Nutrigenetics has been used for decades in certain rare monogenic diseases such as phenylketonuria, and it has the potential to provide a basis for personalized dietary recommendations based on the individual's genetic makeup in order to prevent common multifactorial disorders decades before their clinical manifestation. RECENT FINDINGS: Preliminary results regarding gene-diet interactions in cardiovascular diseases are for the most part inconclusive because of the limitations of current experimental designs. Success in this area will require the integration of various disciplines, and will require investigators to work on large population studies that are designed to investigate gene-environment interactions. SUMMARY: Based on the current knowledge, we anticipate that in the future we will be able to harness the information contained in our genomes to achieve successful aging using behavioral changes, with nutrition being the cornerstone of this endeavor.
机译：审查目的：营养基因组学具有巨大的潜力，可以改变饮食指南和个人建议的未来。营养基因组学涵盖了营养基因组学，它探讨了营养物对基因组，蛋白质组和代谢组以及营养遗传学的影响，其主要目标是阐明遗传变异对饮食与疾病之间相互作用的影响。营养遗传学已经在某些罕见的单基因疾病（例如苯丙酮尿症）中使用了数十年，它有潜力为基于个体的基因组成的个性化饮食建议提供基础，以预防常见的多因素疾病在其临床表现之前的几十年。最近的发现：由于当前实验设计的局限性，关于心血管疾病中基因-饮食相互作用的初步结果在很大程度上不确定。在这一领域的成功将需要整合各个学科，并且将要求研究者进行旨在研究基因与环境相互作用的大型人群研究。总结：基于当前的知识，我们预计，将来我们将能够利用行为改变来利用基因组中包含的信息来成功实现衰老，而营养是这一努力的基石。

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