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Adeno-associated virus delivery of broadly neutralizing antibodies

机译：广泛中和抗体的腺相关病毒传递

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Purpose of Review: In the present review, we will discuss the emerging field of vector-mediated antibody gene transfer as an alternative HIV vaccine. This approach is an improvement over classical passive immunization strategies that administer antibodies to the host to provide protection from infection. With vector-mediated gene transfer, the antibody gene is delivered to the host, resulting in long-term endogenous antibody expression from the injected muscle that confers protective immunity. RECENT FINDINGS: Large numbers of very potent and broadly neutralizing HIV antibodies have recently been isolated and characterized. Vector-mediated antibody gene transfer allows one to immediately use these antibodies as a vaccine. Gene transfer studies in both mice and monkeys demonstrate long-term antibody expression in serum from a single injection at concentrations that provide sterilizing immunity. SUMMARY: Vector-mediated antibody gene transfer can rapidly move existing, potent anti-HIV molecules into the clinic. The gene transfer products demonstrate a potency and breadth identical to the original product. This strategy eliminates the need for immunogen design and interaction with the adaptive immune system to generate protection, a strategy that so far has shown little promise.
机译：综述的目的：在本综述中，我们将讨论载体介导的抗体基因转移作为HIV替代疫苗的新兴领域。该方法是对经典被动免疫策略的改进，该经典被动免疫策略对宿主施用抗体以提供保护以免受感染。通过载体介导的基因转移，抗体基因被传递到宿主，导致注射肌肉长期内源性抗体表达，从而赋予保护性免疫力。最近的发现：最近已经分离并鉴定了许多非常有效且广泛中和的HIV抗体。载体介导的抗体基因转移使人们可以立即将这些抗体用作疫苗。在小鼠和猴子中进行的基因转移研究表明，单次注射后血清中的长期抗体表达可提供杀菌免疫。简介：载体介导的抗体基因转移可以迅速将现有的有效抗HIV分子移入临床。基因转移产物显示出与原始产物相同的效力和广度。这种策略消除了对免疫原设计和与适应性免疫系统相互作用以产生保护作用的需要，迄今为止该策略几乎没有希望。

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