Therapy and clinical trials

Vasutakarn Chongthammakun; Richard A. Krasuski

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Therapy and clinical trials

机译：治疗和临床试验

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The beginning of 2014 was punctuated by the publication of the long-awaited ACC/AHA Blood Cholesterol Guidelines [1]. Compared with ATP-III, this document expanded the estimated number of US statin-eligible adults from 43.4 to 56.0 million, with the majority (10.4 million) having no established cardiovascular disease (CVD), but an elevated 10-year atherosclerotic CVD event risk [2].

机译：2014年初是人们期待已久的ACC / AHA血液胆固醇指南[1]的发布。与ATP-III相比，该文件将符合美国他汀类药物资格的成年人的估计数从43.4扩大到5600万，其中大多数（1,040万）没有既定的心血管疾病（CVD），但是10年的动脉粥样硬化CVD事件风险增加[2]。

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《Current opinion in lipidology》 |2014年第5期|共2页
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Vasutakarn Chongthammakun; Richard A. Krasuski;
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中图分类生物化学;
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1. Re: Liselotte MS Boeve, Maarten CCM Hulshof, Andre N. Vis, et al. Effect on Survival of Androgen Deprivation Therapy Alone Compared to Androgen Deprivation Therapy Combined with Concurrent Radiation Therapy to the Prostate in Patients with Primary Bone Metastatic Prostate Cancer in a Prospective Randomised Clinical Trial: Data from the HORRAD Trial. Eur Urol 2019; 75: 410-8 Future Steps for Definitive Therapy in Metastatic Prostate Cancer: Lessons from the HORRAD Trial [J] . Shinde Ashwin, Li Richard, Amini Arya, European urology . 2019,第3期

机译：Re：Liselotte Ms Boeve，Maarten CCM Hulshof，Andre N. Vis等人。与雄激素剥夺治疗相比，对雄激素剥夺治疗的生存对雄激素剥夺治疗与前瞻性随机临床试验中原发性骨转移前列腺癌前列腺患者的同时剥夺治疗的影响：来自血腥审判的数据。 EUR UROL 2019; 75：410-8转移性前列腺癌中的明确治疗的未来步骤：来自血轮试验的教训
2. ACRNaCT trial protocol: efficacy of adjuvant chemotherapy in patients with clinical T3b/T4, N+ rectal Cancer undergoing Neoadjuvant Chemoradiotherapy: a pathology-oriented, prospective, multicenter, randomized, open-label, parallel group clinical trial [J] . Qingguo Li, Dakui Luo, Ji Zhu, BMC Cancer . 2019,第1期

机译：Actnact试验方案：辅助化疗在临床T3B / T4患者中的疗效，N +直肠癌接受Neoadjuvant ChemorAdiCationaperapy：一种病理到期，前瞻性，多中心，随机，开放标签，并行组临床试验
3. Active immunotherapeutics forum-Advance phase III active immunotherapy programs: just how well did the pre-clinical and early clinical trials translate? Case studies: with the benefit of hindsight, what are the three biggest lessons learned from pre-clinical and early clinical trials? Meeting report from Barcelona, May 12 2011. [J] . Will Colón Human vaccines . 2011,第10期

机译：主动免疫治疗论坛-高级III期主动免疫治疗计划：临床前和早期临床试验的翻译效果如何？案例研究：得益于事后观察，从临床前和早期临床试验中学到的三个最大的教训是什么？巴塞罗那会议报告，2011年5月12日。
4. Derivation and representation of dose-volume response from large clinical trial data sets: an example from the RADAR prostate radiotherapy trial [C] . MA Ebert, K Foo, A Haworth, ICCR . 2014

机译：来自大型临床试验数据组的剂量响应的衍生和表示：雷达前列腺放射治疗试验的一个例子
5. Aging and Disease-modifying Therapies in Multiple Sclerosis: Insights from Clinical Trials and Registries [D] . Zhang, Yinan. 2021

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6. Design and rationale of a multi-center pragmatic open-label randomized trial of antimicrobial therapy – the study of clinical efficacy of antimicrobial therapy strategy using pragmatic design in Idiopathic Pulmonary Fibrosis (CleanUP-IPF) clinical trial [O] . Kevin J. Anstrom, Imre Noth, Kevin R. Flaherty, 2020

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7. The BIG 2.04 MRC/EORTC SUPREMO Trial - Pathology quality assurance of a large phase 3 randomised international clinical trial of postmastectomy radiotherapy in intermediate-risk breast cancer:pathology quality assurance of a large phase 3 randomised international clinical trial of postmastectomy radiotherapy in intermediate-risk breast cancer [O] . Thomas, J S, Hanby, A M, Russell, N, 2017

机译：BIG 2.04 mRC / EORTC sUpREmO试验 - 中度风险乳腺癌切除术后放疗的大型3期随机国际临床试验的病理学质量保证：中度风险乳房切除术后放疗的大型3期随机国际临床试验的病理学质量保证乳腺癌

Therapy and clinical trials

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