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5-Lipoxygenase and atherosclerosis.

机译:5-脂氧合酶和动脉粥样硬化。

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SUMMARY: PURPOSE OF REVIEW 5-Lipoxygenase (5LO) was recently identified as a gene that makes an important contribution to atherosclerosis in mice and humans, but the underlying mechanism(s) remains unknown.RECENT FINDINGS Studies of the 5LO pathway in other disease areas suggest that 5LO could contribute to atherosclerosis at different levels, such as lesion initiation, growth and cellular proliferation within the lesion, and/or destabilization of plaques that can lead to their rupture.SUMMARY Recent advances in our understanding of how 5LO is involved in the atherosclerotic process will have important implications for diagnostic and therapeutic strategies in the future.
机译:摘要:审查的目的5-脂氧合酶(5LO)最近被鉴定为对小鼠和人类的动脉粥样硬化做出重要贡献的基因,但其潜在机制仍然未知。最近的发现其他疾病领域中5LO途径的研究提示5LO可能在不同水平上促进动脉粥样硬化,例如病变的开始,病变内的生长和细胞增殖和/或可能导致斑块破裂的斑块不稳定。动脉粥样硬化过程将对未来的诊断和治疗策略产生重要影响。

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