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首页> 外文期刊>Current opinion in lipidology >Lipid metabolism.
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Lipid metabolism.

机译：脂质代谢。

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摘要

There is considerable evidence that a diet rich in polyunsaturatedfatty acids, especially omega-3 fatty acids derived from oily fish or nuts, is associated with reduced cardiovascular morbidity and mortality, and in particular a decrease in sudden cardiac death, although results of meta-analysis remain equivocal . Several mechanisms have been proposed to explain this effect. Incorporation of fatty acids into myocardial membranes may influence ion channel function and reduce the risk of cardiac dysrhythmias . In addition, omega-3 fatty acids lower triglycerides, reduce platelet aggregation, and improve arterial endothelial function . Omega-3 fatty acids are also nutritional regulators of gene transcription, interacting with several different transcription factors to influence the expression of a range of genes, including genes involved in the regulation of inflammation and expression of adhesion molecules .
机译：有大量证据表明，尽管荟萃分析的结果表明，富含多不饱和脂肪酸（尤其是源自油性鱼或坚果的omega-3脂肪酸）的饮食可降低心血管疾病的发病率和死亡率，尤其是减少心源性猝死。保持模棱两可。已经提出了几种机制来解释这种效果。将脂肪酸掺入心肌膜中可能会影响离子通道功能，并降低发生心律不齐的风险。此外，omega-3脂肪酸可降低甘油三酸酯，减少血小板聚集并改善动脉内皮功能。 Omega-3脂肪酸还是基因转录的营养调节剂，它与几种不同的转录因子相互作用，影响一系列基因的表达，包括参与炎症调节和粘附分子表达的基因。

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