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Hippo signalling during development

机译:河马信号在开发期间

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摘要

The Hippo signalling pathway and its transcriptional co-activator targets Yorkie/YAP/TAZ first came to attention because of their role in tissue growth control. Over the past 15 years, it has become clear that, like other developmental pathways (e.g. the Wnt, Hedgehog and TGF beta pathways), Hippo signalling is a jack of all trades' that is reiteratively used to mediate a range of cellular decision-making processes from proliferation, death and morphogenesis to cell fate determination. Here, and in the accompanying poster, we briefly outline the core pathway and its regulation, and describe the breadth of its roles in animal development.
机译:由于它们在组织生长控制中的作用,河马信号通路及其转录共同激活靶标Yickie / Yap / Taz首先引起了关注。 在过去的15年中,它已经清楚地清楚地,与其他发展途径一样(例如WNT,刺猬和TGF Beta途径),河马信号传导是所有交易的千斤顶,这是重复使用的,用于调解一系列蜂窝决策 从增殖,死亡和形态发生到细胞命运测定的过程。 在这里,在附带海报中,我们简要概述了核心途径及其调节,并描述了在动物发育中的作用的宽度。

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