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Genetic Predisposition to Central Obesity and Risk of Type 2 Diabetes: Two Independent Cohort Studies

机译：遗传倾向于中央肥胖和2型糖尿病风险：两个独立的队列研究

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摘要

OBJECTIVEAbdominal obesity is a major risk factor for type 2 diabetes (T2D). We aimed to examine the association between the genetic predisposition to central obesity, assessed by the waist-to-hip ratio (WHR) genetic score, and T2D risk.RESEARCH DESIGN AND METHODSThe current study included 2,591 participants with T2D and 3,052 participants without T2D of European ancestry from the Nurses' Health Study (NHS) and the Health Professionals Follow-up Study (HPFS). Genetic predisposition to central obesity was estimated using a genetic score based on 14 established loci for the WHR.RESULTSWe found that the central obesity genetic score was linearly related to higher T2D risk. Results were similar in the NHS (women) and HPFS (men). In combined results, each point of the central obesity genetic score was associated with an odds ratio (OR) of 1.04 (95% CI 1.01-1.07) for developing T2D, and the OR was 1.24 (1.03-1.45) when comparing extreme quartiles of the genetic score after multivariate adjustment.CONCLUSIONSThe data indicate that genetic predisposition to central obesity is associated with higher T2D risk. This association is mediated by central obesity.
机译：特视角肥胖是2型糖尿病（T2D）的主要危险因素。我们旨在检查遗传易感性对中央肥胖之间的关联，由腰臀比（WHR）遗传分数和T2D风险评估。研究设计和方法目前的研究包括2,591名与T2D和3,052名参与者没有T2D的参与者来自护士的欧洲祖先（NHS）和卫生专业人员随访研究（HPF）。使用基于14个已成立的基因座的遗传分数估计了对中央肥胖的遗传倾向估计了遗传评分，因为WHR.Resultwe发现中央肥胖遗传分数与较高的T2D风险线性相关。 NHS（女性）和HPFS（男性）的结果相似。在组合结果中，中央肥胖遗传分数的每个点与1.04（45％CI 1.01-1.07）的差距（或）有关，用于在比较极端四分位数时，或1.24（1.03-1.45）多元调整后的遗传分数。结论数据表明，中央肥胖的遗传倾向与T2D风险更高。该协会是由中央肥胖的介导的。

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  • 来源
    《Diabetes care》 |2015年第7期|共6页
  • 作者

    Huang Tao; Qi Qibin; Zheng Yan; Ley Sylvia H.; Manson JoAnn E.; Hu Frank B.; Qi Lu;

  • 作者单位

    Harvard Univ Sch Publ Hlth Dept Nutr Boston MA 02115 USA;

    Albert Einstein Coll Med Dept Epidemiol &

    Populat Hlth Bronx NY 10467 USA;

    Harvard Univ Sch Publ Hlth Dept Nutr Boston MA 02115 USA;

    Harvard Univ Sch Publ Hlth Dept Nutr Boston MA 02115 USA;

    Brigham &

    Womens Hosp Dept Med Channing Div Network Med Boston MA 02115 USA;

    Harvard Univ Sch Publ Hlth Dept Nutr Boston MA 02115 USA;

    Harvard Univ Sch Publ Hlth Dept Nutr Boston MA 02115 USA;

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  • 正文语种 eng
  • 中图分类 内分泌腺疾病及代谢病;
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