...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Diabetes care >Association of clinical symptomatic hypoglycemia with cardiovascular events and total mortality in type 2 diabetes: A nationwide population-based study
【24h】

Association of clinical symptomatic hypoglycemia with cardiovascular events and total mortality in type 2 diabetes: A nationwide population-based study

机译：临床症状低血糖症与2型糖尿病患者心血管事件的临床症状和总死亡率：全国范围的人口研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE-Hypoglycemia is associated with serious health outcomes for patients treated for diabetes. However, the outcome of outpatients with type 2 diabetes who have experienced hypoglycemia episodes is largely unknown. RESEARCH DESIGN AND METHODS-The study population, derived from the National Health Insurance Research Database released by the Taiwan National Health Research Institutes during 1998-2009, comprised 77,611 patients with newly diagnosed type 2 diabetes. We designed a prospective study consisting of randomly selected hypoglycemic type 2 diabetic patients and matched type 2 diabetic patients without hypoglycemia. We investigated the relationships of hypoglycemia with total mortality and cardiovascular events, including stroke, coronary heart disease, cardiovascular diseases, and all-cause hospitalization. RESULTS-Therewere 1,844 hypoglycemic events (500 inpatients and 1,344 outpatients)among the 77,611 patients. Both mild (outpatient) and severe (inpatient) hypoglycemia cases had a higher percentage of comorbidities, including hypertension, renal diseases, cancer, stroke, and heart disease. In multivariate Cox regression models, including diabetes treatment adjustment, diabetic patients with hypoglycemia had a significantly higher risk of cardiovascular events during clinical treatment periods. After constructing a model adjusted with propensity scores, mild and severe hypoglycemia still demonstrated higher hazard ratios (HRs) for cardiovascular diseases (HR 2.09 [95% CI 1.63- 2.67]), all-cause hospitalization (2.51 [2.00-3.16]), and total mortality (2.48 [1.41-4.38]). CONCLUSIONS-Symptomatic hypoglycemia, whether clinically mild or severe, is associated with an increased risk of cardiovascular events, all-cause hospitalization, and all-cause mortality. More attention may be needed for diabetic patients with hypoglycemic episodes. ? 2013 by the American Diabetes Association.
机译：目的 - 低聚血症与治疗糖尿病治疗的患者的严重健康结果有关。然而，具有经历的低血糖发作的2型糖尿病的门诊患者的结果在很大程度上是未知的。研究设计和方法 - 来自1998 - 2009年的台湾国家卫生研究机构的国家健康保险研究数据库的研究人口，包括77,611名患有新诊断的2型糖尿病患者。我们设计了一项前瞻性研究，包括随机选择的低血糖2型糖尿病患者，匹配2型糖尿病患者没有低血糖症。我们调查了低血糖与总死亡率和心血管事件的关系，包括中风，冠心病，心血管疾病和全因住院治疗。结果 - 77,611名患者中有1,844例低血糖事件（500名住院患者和1,344名门诊）。轻度（门诊）和严重（住院病时）的低血糖病例均具有更高的合并症，包括高血压，肾病，癌症，中风和心脏病。在多变量Cox回归模型中，包括糖尿病治疗调整，患有低血糖患者的糖尿病患者在临床治疗期间的心血管事件风险显着。在构建具有倾向分数的模型之后，轻度和严重的低血糖仍然表现出心血管疾病的危险比（HRS）较高（HR 2.09 [95％CI 1.63-2.67]），全部原因住院治疗（2.51 [2.00-3.16]），和总死亡率（2.48 [1.41-4.38]）。结论 - 症状低血糖症，无论临床上轻度还是严重，都与心血管事件的风险增加，全面住院和全导致死亡率有关。糖尿病患者可能需要更加关注糖尿病患者的低血糖发作。还是2013年由美国糖尿病协会。

著录项

  • 来源
    《Diabetes care》 |2013年第4期|共7页
  • 作者

    HsuP.-F.; SungS.-H.; ChengH.-M.; YehJ.-S.; LiuW.-L.; ChanW.-L.; ChenC.-H.; ChouP.; ChuangS.-Y.;

  • 作者单位

    Healthcare and Management Center Taipei Veterans General Hospital Taipei Taiwan Department of;

    Department of Medicine National Yang-Ming University Taipei Taiwan Institute of Public Health;

    Department of Medicine National Yang-Ming University Taipei Taiwan Joanna Briggs Institute;

    Internal Medicine Department Taipei Medical University Wan-Fang Hospital Taipei Taiwan;

    Institute of Population Health Sciences National Health Research Institutes Miaoli Taiwan;

    Healthcare and Management Center Taipei Veterans General Hospital Taipei Taiwan Cardiology;

    Department of Medicine National Yang-Ming University Taipei Taiwan Institute of Public Health;

    Institute of Public Health Community Medicine Research Center National Yang-Ming University;

    Institute of Population Health Sciences National Health Research Institutes Miaoli Taiwan;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 内分泌腺疾病及代谢病;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号