Primary prevention of macroangiopathy in patients with short-duration type 2 diabetes by intensified multifactorial intervention: Seven-year follow-up of diabetes complications in Chinese

YangY.; YaoJ.-J.; DuJ.-L.; BaiR.; SunL.-P.; SunG.-H.; SongG.-R.; CaoS.-M.; ShiC.-H.; BaY.; XingQ.; ZhangX.-Y.

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Primary prevention of macroangiopathy in patients with short-duration type 2 diabetes by intensified multifactorial intervention: Seven-year follow-up of diabetes complications in Chinese

机译：短期患者的宏观管病初级预防2型糖尿病加强多因素干预：七年后的糖尿病并发症

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OBJECTIVE-To explore whether intensified, multifactorial intervention could prevent macrovascular disease in patients with recently diagnosed type 2 diabetes. RESEARCH DESIGN AND METHODS-A total of 150 type 2 diabetic patients, with disease duration of <1 year and without clinical arteriosclerotic disease or subclinical atherosclerotic signs confirmed by ultrasonographic scanning of three conducting arteries, were randomized into an intensive intervention group and a conventional intervention group. They then received intensive, multifactorial intervention or conventional intervention over 7 years of follow-up. The patients' common carotid intima-media thicknesses (CC-IMTs) were measured every year. The primary outcome was the time to the first occurrence of CC-IMTs??1.0mm and/ or development of atherosclerosis plaques in the carotid artery. The secondary outcome was clinical evidence of cardiovascular disease. RESULTS-A total of 70 patients in the intensive group and 68 patients in the conventional group completed the 7-year follow-up. Subclinical macrovascular (primary) outcomes occurred in seven cases in the intensive group and 22 cases in the conventional group for a cumulative prevalence of 10.00 and 32.35%, respectively (P <0.05). No significant differences between the two groups were observed regarding the secondary outcome. CONCLUSIONS-Primary prevention of macrovascular diseases can be achieved through intensified, multifactorial intervention in patients with short-duration type 2 diabetes. Type 2 diabetic patients should undergo intensivemultifactorial interventionswith individual targets for the prevention of macrovascular diseases. ? 2013 by the American Diabetes Association.

机译：目的 - 探索是否会愈合，患有最近诊断的2型糖尿病患者的大血管疾病。研究设计和方法 - 共有150型糖尿病患者，疾病持续时间为<1年，没有临床动脉粥样硬化疾病或通过超声扫描的三个导电动脉证实的亚临床动脉粥样硬化符号，被随机分为一个密集的干预组和常规干预团体。然后，他们收到了超过7年的后续行动的密集，多因素干预或传统干预。每年测量患者常见的颈动脉内膜介质厚度（CC-IMT）。主要结果是第一次发生CC-IMT的时间和/或在颈动脉中动脉粥样硬化斑块的发展。次要结果是心血管疾病的临床证据。结果 - 共有70名患者在密集型组和68名常规组患者中完成了7年的随访。亚临床大脑（初级）结果发生在七种病例中，在密集组和常规组中的22例分别为10.00％和32.35％（P <0.05）。关于二次结果没有观察到两组之间的显着差异。结论致血管疾病的初步预防通过强化，患有短期2型糖尿病患者的患者可以实现血管疾病。 2型糖尿病患者应接受患有预防宏观血管疾病的个体目标的强烈术语。还是2013年由美国糖尿病协会。

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来源
《Diabetes care》 |2013年第4期|共7页
作者
YangY.; YaoJ.-J.; DuJ.-L.; BaiR.; SunL.-P.; SunG.-H.; SongG.-R.; CaoS.-M.; ShiC.-H.; BaY.; XingQ.; ZhangX.-Y.;
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Department of Endocrinology First Affiliated Hospital Dalian Medical University Dalian China;

Department of Endocrinology First Affiliated Hospital Dalian Medical University Dalian China;

Department of Endocrinology First Affiliated Hospital Dalian Medical University Dalian China;

Department of Endocrinology First Affiliated Hospital Dalian Medical University Dalian China;

Department of Ultrasonography First Affiliated Hospital Dalian Medical University Dalian China;

Department of Clinical Laboratory First Affiliated Hospital Dalian Medical University Dalian;

Department of Health Statistics Dalian Medical University Dalian China;

Department of Endocrinology First Affiliated Hospital Dalian Medical University Dalian China;

Department of Endocrinology First Affiliated Hospital Dalian Medical University Dalian China;

Department of Endocrinology First Affiliated Hospital Dalian Medical University Dalian China;

Department of Endocrinology First Affiliated Hospital Dalian Medical University Dalian China;

Department of Endocrinology First Affiliated Hospital Dalian Medical University Dalian China;

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正文语种 eng
中图分类内分泌腺疾病及代谢病;
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Primary prevention of macroangiopathy in patients with short-duration type 2 diabetes by intensified multifactorial intervention: Seven-year follow-up of diabetes complications in Chinese

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