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首页> 外文期刊>Diabetes care >Randomized study comparing a Basal-bolus with a Basal plus correction insulin regimen for the hospital management of medical and surgical patients with type 2 diabetes: Basal plus trial.
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Randomized study comparing a Basal-bolus with a Basal plus correction insulin regimen for the hospital management of medical and surgical patients with type 2 diabetes: Basal plus trial.

机译：随机研究将基底推注与基础加号矫正胰岛素方案进行比较，用于医院管理2型糖尿病患者的医院管理：基础加上试验。

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OBJECTIVE Effective and easily implemented insulin regimens are needed to facilitate hospital glycemic control in general medical and surgical patients with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS This multicenter trial randomized 375 patients with T2D treated with diet, oral antidiabetic agents, or low-dose insulin (≤0.4 units/kg/day) to receive a basal-bolus regimen with glargine once daily and glulisine before meals, a basal plus regimen with glargine once daily and supplemental doses of glulisine, and sliding scale regular insulin (SSI). RESULTS Improvement in mean daily blood glucose (BG) after the first day of therapy was similar between basal-bolus and basal plus groups (P = 0.16), and both regimens resulted in a lower mean daily BG than did SSI (P = 0.04). In addition, treatment with basal-bolus and basal plus regimens resulted in less treatment failure (defined as >2 consecutive BG >240 mg/dL or a mean daily BG >240 mg/dL) than did treatment with SSI (0 vs. 2 vs. 19%, respectively; P < 0.001). A BG <70 mg/dL occurred in 16% of patients in the basal-bolus group, 13% in the basal plus group, and 3% in the SSI group (P = 0.02). There was no difference among the groups in the frequency of severe hypoglycemia (<40 mg/dL; P = 0.76). CONCLUSIONS The use of a basal plus regimen with glargine once daily plus corrective doses with glulisine insulin before meals resulted in glycemic control similar to a standard basal-bolus regimen. The basal plus approach is an effective alternative to the use of a basal-bolus regimen in general medical and surgical patients with T2D.
机译：客观有效且易于实施的胰岛素方案需要促进一般医疗和手术患者的医院血糖控制（T2D）。研究设计与方法本多中心试验随机治疗375名T2D患者用饮食，口服抗糖尿病药物治疗，或低剂量胰岛素（≤0.4单位/千克/天），以在饭前每日和青少年接受肺碱的基础推注制造方案，基础加上狼狼每日一次和补充剂量的青少年剂量，以及滑动级常规胰岛素（SSI）。结果在基底推注和基础加上基础加上的第一天（P = 0.16）之间的疗法第一天血糖（BG）的平均日常血糖（BG）改善（P = 0.16），并且两种方案导致较低的平均BG比SSI（P = 0.04） 。此外，用基底推注和基础加上的治疗方法导致较少的治疗失败（定义为240mg / dL或平均每日BG> 240mg / dL），而不是用SSI的处理（0 Vs.2与19％分别; p <0.001）。 BG <70mg / DL发生在基底推注组中16％的患者，13％在基础加组中，SSI组3％（P = 0.02）。在严重的低血糖频率的群体中没有差异（<40mg / dl; p = 0.76）。结论使用基础加上的狼吞虎咽治疗每日加上乳胶蛋白胰岛素的矫形剂量，导致血糖胰岛素导致血糖控制类似于标准的基础推注方案。基础加上方法是在General医学和手术患者中使用基础推子方案的有效替代方案。

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