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首页> 外文期刊>Journal of Alloys and Compounds: An Interdisciplinary Journal of Materials Science and Solid-state Chemistry and Physics >Determination of ideal Mg-35Zn-xCa alloy depending on Ca concentration for biomaterials
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Determination of ideal Mg-35Zn-xCa alloy depending on Ca concentration for biomaterials

机译：取决于生物材料CA浓度的理想Mg-35Zn-XCA合金的测定

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摘要

Mg is a potential material for orthopedic and craniofacial implants. However, the failure of peri-implant osseointegration often occurs because pure Mg corrodes rapidly and has low mechanical strength. This study aimed to overcome these limitations via the development of various Mg-35Zn-xCa alloys. Electrochemical and immersion corrosion of these alloys were examined in simulated body fluid, and their cytotoxicity (cell proliferation and morphology) was assessed in a mouse osteoblast cell (MC3T3-E1). Structural analysis revealed that the Mg-35Zn-xCa alloys had a dendritic composition. The volume fractions of the second phases (Mg2Ca and Ca2Mg6Zn3) in the alloys increased with an increase in Ca concentration. The Mg-35Zn-xCa (x = 2, 3) alloys displayed greater hardness values (p 0.05) and better corrosion resistance than the others; the Mg-35Zn-2Ca displayed the highest Ecorr and lowest Icorr value. Cells of all groups had extended filopodia, thereby indicating that cell adhesion was intact. At each time point, the number of attached cells was the highest in the extracted media of Mg-35Zn-2Ca alloy, indicating that this material has good osteoconductivity. Based on the mechanical, corrosive, and biological properties, the Mg-35Zn-2Ca alloy can be a useful biomaterial for orthopedic implants. (C) 2018 Elsevier B.V. All rights reserved.
机译：Mg是矫形和颅面植入物的潜在材料。然而，常植入骨整合的失败经常出现，因为纯MG迅速腐蚀并且机械强度低。本研究旨在通过各种Mg-35zn-XCA合金的发展克服这些限制。在模拟体液中检测这些合金的电化学和浸渍腐蚀，并在小鼠成骨细胞（MC3T3-E1）中评估它们的细胞毒性（细胞增殖和形态）。结构分析显示Mg-35Zn-XCA合金具有树枝状组合物。在合金中的第二阶段（Mg2Ca和Ca2mg6zN3）的体积分数随Ca浓度的增加而增加。 Mg-35Zn-XCA（X = 2,3）合金显示出更大的硬度值（P <0.05），更好的耐腐蚀性; MG-35ZN-2CA显示了最高的ECORR和最低ICORR值。所有基团的细胞延长了氟化碳腺炎，从而表明细胞粘附完整。在每个时间点，连接细胞的数量是Mg-35zn-2Ca合金的提取介质中最高的，表明该材料具有良好的骨导电性。基于机械，腐蚀性和生物特性，Mg-35Zn-2Ca合金可以是用于整形外科植入物的有用生物材料。 （c）2018年elestvier b.v.保留所有权利。

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