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首页> 外文期刊>Journal of Neurophysiology >Cerebellar fastigial nucleus influence on ipsilateral abducens activity during saccades
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Cerebellar fastigial nucleus influence on ipsilateral abducens activity during saccades

机译：小脑发短核对扫描期间同侧Abducens活性的影响

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摘要

To characterize the cerebellar influence on neurons in the abducens (ABD) nucleus, we recorded ABD neurons before and after we inactivated the caudal part of the ipsilateral cerebellar fastigial nucleus (cFN) with muscimol injection. cFN activity influences the horizontal component of saccades. cFN inac-tivation increased the activity of most ipsilateral ABD neurons (19/22 in 2 monkeys) during ipsiversive (hypermetric) saccades, primarily by increasing burst duration. During contraversive (hypometric) saccades, the off-direction pause of most (10/15) ABD neurons was shorter than normal because of the early resumption of ABD activity. Early ABD firing caused the early contraction of antagonist muscles that reduced eye rotation and made contraversive saccades hypometric. Thus the cerebellum controls ipsilateral ABD activity by truncating on-direction bursts during ipsiversive saccades and extending off-direction pauses during contraversive saccades. We conclude that cFN output keeps saccades accurate by controlling when ABD on-direction bursts and off-direction pauses end.
机译：为了表征ABDUCENS（ABD）核中的神经元的小脑影响，我们在用Muscimol注射液体灭活的同侧小脑短核（CFN）的尾部部分之前和之后记录了ABD神经元。 CFN活性影响扫视的水平分量。 CFN Inac-Tivation在IPsiversive（超细）扫描期间增加了大多数Ipsilateral ABD神经元（19/22在2只猴子）的活性，主要通过增加突发持续时间。在矛盾（低度）扫描期间，由于早期恢复ABD活性，大多数（10/15）ABD神经元的脱向暂停短于正常。早期的ABD烧制导致拮抗剂肌肉的早期收缩，减少眼睛旋转并使逆向扫描囊肿。因此，小脑通过在IPSiversive扫描期间截断在方向上的爆裂并在逆向扫描期间延伸脱向暂停来控制同侧ABD活性。我们得出结论，CFN输出通过控制ABD在方向突发和偏离方向暂停结束时通过控制来保持扫视。

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