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首页> 外文期刊>Journal of Neurophysiology >Age-dependent adrenergic actions in the main olfactory bulb that could underlie an olfactory-sensitive period
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Age-dependent adrenergic actions in the main olfactory bulb that could underlie an olfactory-sensitive period

机译：在主要嗅灯泡中的年龄依赖性肾上腺素能动作，可以提出嗅觉敏感期

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Many sensory systems are endowed with mechanisms of neural plasticity that are restricted to a sensitive period in the young developing animal. In this study, we performed experiments in slices of the main olfactory bulb (OB) from rats to examine possible age-dependent cellular mechanisms of plasticity in the olfactory system. We focused on the neurotransmitter norepinephrine (NE), shown to be important in different forms of olfactory learning, examining whether two specific cellular effects of NE previously observed in rats less than P14 extended to older animals. These included an acute reduction in GABAergic synaptic transmission from granule cells (GCs) onto output mitral cells (MCs) and an enhancement in gamma frequency (30-70 Hz) oscillations that persists long after removal of NE. We found that NE failed to reduce GC-to-MC transmission or enhance gamma oscillations in older rats at PI8-23. The loss of NE actions on both phenomena appeared to reflect an age-dependent loss of function of a2-adrenergic receptors. In addition, we found that NE induced an age-dependent enhancement of transient excitation in MCs, providing a mechanism to link the acute decrease in GC-to-MC inhibition to the long-term increase in gamma oscillations through increases in intracellular calcium. The age-dependent cellular mechanisms that we describe could underlie an olfactory-sensitive period in newborn rodents.
机译：许多感官系统具有神经可塑性的机制，其限于幼年发展动物中的敏感时期。在这项研究中，我们在大鼠的主要嗅灯泡（OB）的切片中进行了实验，以检查嗅觉系统中可塑性的可能年龄依赖性细胞机制。我们专注于神经递质去甲肾上腺素（NE），表明在不同形式的嗅觉学习中是重要的，检查先前在大鼠延伸到旧动物的大鼠中是否观察到的TE的两种特异性细胞效应。其中包括从颗粒细胞（GCS）到输出二尖瓣（MCS）上的急性降低了从颗粒细胞（GCS）和伽马频率（30-70Hz）振荡的增强，在去除NE之后持续存在。我们发现NE未能降低GC-TO-MC传输或在PI8-23的较旧大鼠中增强伽马振荡。两种现象的NE行动的丧失似乎反映了A2-肾上腺素能受体的年龄依赖性丧失。此外，我们发现NE诱导MCS中瞬态激发的年龄依赖性增强，提供了将GC-〜MC抑制的急性降低链接到Gamma振荡的长期增加通过细胞内钙的增加。我们描述的年龄依赖性细胞机制可能使新生儿啮齿动物的嗅觉敏感时期提高。

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