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首页> 外文期刊>Journal of Neurophysiology >Intrinsic physiological properties of rat retinal ganglion cells with a comparative analysis
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Intrinsic physiological properties of rat retinal ganglion cells with a comparative analysis

机译：具有比较分析的大鼠视网膜神经节细胞的内在生理特性

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摘要

Mammalian retina contains 15-20 different retinal ganglion cell (RGC) types, each of which is responsible for encoding different aspects of the visual scene. The encoding is defined by a combination of RGC synaptic inputs, the neurotransmitter systems used, and their intrinsic physiological properties. Each cell's intrinsic properties are defined by its morphology and membrane characteristics, including the complement and localization of the ion channels expressed. In this study, we examined the hypothesis that the intrinsic properties of individual RGC types are conserved among mammalian species. To do so, we measured the intrinsic properties of 16 morphologically defined rat RGC types and compared these data with cat RGC types. Our data demonstrate that in the rat different morphologically defined RGC types have distinct patterns of intrinsic properties. Variation in these properties across cell types was comparable to that found for cat RGC types. When presumed morphological homologs in rat and cat retina were compared directly, some RGC types had very similar properties. The rat A2 cell exhibited patterns of intrinsic properties nearly identical to the cat alpha cell. In contrast, rat D2 cells (ON-OFF directionally selective) had a very different pattern of intrinsic properties than the cat iota cell. Our data suggest that the intrinsic properties of RGCs with similar morphology and suspected visual function may be subject to variation due to the behavioral needs of the species.
机译：哺乳动物视网膜含有15-20种不同的视网膜神经节细胞（RGC）类型，每个类型的类型负责编码视觉场景的不同方面。编码由RGC突触输入，所使用的神经递质系统的组合和它们的内在生理特性来定义。每个细胞的内在特性由其形态和膜特性定义，包括所表达的离子通道的补体和定位。在这项研究中，我们检查了哺乳动物种类中单个RGC类型的内在性质的假设。为此，我们测量了16种形态定义的大鼠RGC类型的内在特性，并将这些数据与CAT RGC类型进行了比较。我们的数据表明，在大鼠不同形态学定义的RGC类型具有不同的内在特性模式。跨细胞类型的这些属性的变化与CAT RGC类型的类型相当。当直接比较大鼠和猫视网膜的预测形态同源物时，一些RGC类型具有非常相似的性质。大鼠A2细胞表现出与猫α细胞几乎相同的内在特性的图案。相反，大鼠D2细胞（ON-OFF定向选择性）具有比猫IOTA细胞的内在性质的非常不同的模式。我们的数据表明，由于物种的行为需求，RGCs具有相似形态和疑似视觉功能的RGC的内在特性可能受到变化。

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