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首页> 外文期刊>Journal of Neurophysiology >Pitfalls in the dipolar model for the neocortical EEG sources
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Pitfalls in the dipolar model for the neocortical EEG sources

机译：Neocortical EEG来源的偶极模型中的陷阱

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For about six decades, primary current sources of the electroencephalogram (EEG) have been assumed dipolar in nature. In this study, we used electrophysiological recordings from anesthetized Wistar rats undergoing repeated whisker deflections to revise the biophysical foundations of the EEG dipolar model. In a first experiment, we performed three-dimensional recordings of extracellular potentials from a large portion of the barrel field to estimate intracortical multipolar moments generated either by single spiking neurons (i.e., pyramidal cells, PC; spiny stellate cells, SS) or by populations of them while experiencing synchronized postsynaptic potentials. As expected, backpropagating spikes along PC dendrites caused dipolar field components larger in the direction perpendicular to the cortical surface (49.7 ± 22.0 nA·mm). In agreement with the fact that SS cells have "close-field" configurations, their dipolar moment at any direction was negligible. Surprisingly, monopolar field components were detectable both at the level of single units (i.e., -11.7 ± 3.4 nA for PC) and at the mesoscopic level of mixed neuronal populations receiving extended synaptic inputs within either a cortical column (-0.44 ± 0.20 μA) or a 2.5-m3-voxel volume (-3.32 ± 1.20 μA). To evaluate the relationship between the macroscopically defined EEG equivalent dipole and the mesoscopic intracortical multipolar moments, we performed concurrent recordings of high-resolution skull EEG and laminar local field potentials. From this second experiment, we estimated the time-varying EEG equivalent dipole for the entire barrel field using either a multiple dipole fitting or a distributed type of EEG inverse solution. We demonstrated that mesoscopic multipolar components are altogether absorbed by any equivalent dipole in both types of inverse solutions. We conclude that the primary current sources of the EEG in the neocortex of rodents are not precisely represented by a single equivalent dipole and that the existence of monopolar components must be also considered at the mesoscopic level. ? 2012 the American Physiological Society.
机译：大约六十年来，脑电图（EEG）的初级电流源已经假设了偶极性。在这项研究中，我们使用从经历重复的晶须偏转的麻醉Wistar大鼠的电生理记录来修改EEG偶极模型的生物物理基础。在第一次实验中，我们从大部分桶场进行了细胞外电位的三维​​记录，以估计单一尖刺神经元（即金字塔细胞，PC;刺刺斑块细胞，SS）或群体产生的内部多极体矩在遇到同步的突触突前潜力的同时。正如所料，沿PC枝条的反向慢化尖峰在垂直于皮质表面的方向上导致偶极场部件（49.7±22.0 na·mm）。同意SS细胞具有“近场”配置的事实，任何方向的双极力矩都可以忽略不计。令人惊讶的是，单位单位（IE，PC -11.7±3.4 NA）和在皮质柱内的混合神经元群体的介观水平上检测单位单位（即-11.7±3.4 NA）和介乎突触的神经元群体（-0.44±0.20μA）的混合神经元群体的介观或2.5-m3- voxel体积（-3.32±1.20μA）。为了评估宏观定义的脑电图等效偶极子与介于介绍性的偶像性多极力矩之间的关系，我们执行了高分辨率颅骨EEG和层内场电位的并行记录。从该第二实验，我们估计了使用多偶极拟合或分布式EEG逆解决方案的整个桶场的时变eEG等效偶极子。我们证明了介观多极组分在两种逆溶液中由任何等同的偶极吸收。我们得出结论，啮齿动物Neocortex中的脑电图的主要电流源不被单一的等效偶极精确表示，并且必须在介术水平上考虑单极组分的存在。还是2012年美国生理社会。

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