...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neurophysiology >Fluoxetine reverses brain radiation and temozolomide-induced anxiety an spatial learning and memory defect in mice
【24h】

Fluoxetine reverses brain radiation and temozolomide-induced anxiety an spatial learning and memory defect in mice

机译：氟西汀逆转脑辐射和替莫唑族诱导的焦虑小鼠的空间学习和记忆缺陷

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Radiation therapy and concomitant temozolomide chemotherapy are commonly used in treatment of brain tumors, but they may also result in behavioral impairments such as anxiety and cognitive deficit. The present study sought to investigate the effect of fluoxetine on the behavioral impairments caused by radiation and temozolomide treatment. C57BL/6J mice were subjected to a single cranial radiation followed by 6-wk cyclic temozolomide administration and were then treated with chronic administration of fluoxetine. Behavioral tests were carried out to determine the anxiety-like behavior and cognition function of these animals. Long-term potentiation (LTP) in the hippocampus was measured by electrophysiology, and neurogenesis in the dentate gyms was evaluated by immunohistochemistry. Mice treated with radiation and temozolomide showed increased anxiety-like behavior and cognitive impairment, along with LTP impairment and neurogenesis deficit. Chronic fluoxetine administration could reverse the behavioral dysfunction, enhance LTP, and increase neurogenesis in the hippocampus.
机译：放射疗法和伴随的替替莫唑胺化学疗法通常用于治疗脑肿瘤，但它们也可能导致行为损伤，例如焦虑和认知缺陷。本研究试图探讨氟西汀对辐射和灭菌治疗引起的行为损伤的影响。将C57BL / 6J小鼠进行单个颅辐射，然后进行6-WK环旋毒物施用，然后用慢性施用氟西汀处理。进行行为试验以确定这些动物的焦虑性行为和认知功能。海马的长期增强（LTP）通过电生理学测量，牙齿健身房中的神经发生通过免疫组织化学评估。用辐射和替替唑胺治疗的小鼠表现出增加的焦虑行为和认知障碍，以及LTP障碍和神经发生缺陷。慢性氟西汀给药可以逆转行为功能障碍，增强LTP，增加海马中的神经发生。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号