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首页> 外文期刊>Journal of Neurophysiology >BDNF Val66Met polymorphism alters spinal DC stimulation-induced plasticity in humans
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BDNF Val66Met polymorphism alters spinal DC stimulation-induced plasticity in humans

机译：BDNF Val66met多态性改变了人类的脊柱直流刺激诱导的可塑性

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摘要

The brain-derived neurotrophic factor gene (BDNF) is one of many genes thought to influence neuronal survival, synaptic plasticity, and neurogenesis. A common single nucleotide polymorphism (SNP) of the BDNF gene due to valine-to-methionine substitution at codon 66 (BDNF Val66Met) in the normal population has been associated with complex neuronal phenotype, including differences in brain morphology, episodic memory, or cortical plasticity following brain stimulation and is believed to influence synaptic changes following motor learning task. However, the effect of this polymorphism on spinal plasticity remains largely unknown. Here, we used anodal transcutaneous spinal direct current stimulation (tsDCS), a novel noninvasive technique that induces plasticity of spinal neuronal circuits in healthy subjects. To investigate whether the susceptibility of tsDCS probes of spinal plasticity is significantly influenced by BDNF polymorphism, we collected stimulus-response curves of the soleus (Sol) H reflex before, during, at current offset, and 15 min after anodal tsDCS delivered at Th11 (2.5 mA, 15 min, 0.071 mA/cm2, and 64 mC/cm2) in 17 healthy, Met allele carriers and 17 Val homozygotes who were matched for age and sex. Anodal tsDCS induced a progressive leftward shift of recruitment curve of the H reflex during the stimulation that persisted for at least 15 min after current offset in Val/Val individuals. In contrast, this shift was not observed in Met allele carriers. Our findings demonstrate for the first time that the BDNF Val66Met genotype impacts spinal plasticity in humans, as assessed by tsDCS, and may be one factor influencing the natural response of the spinal cord to injury or disease.
机译：脑衍生的神经营养因子基因（BDNF）是许多基因中，旨在影响神经元存活，突触塑性和神经发生的基因之一。在正常群体中，在密码子66（BDNF Val66met）的缬氨酸对甲硫氨酸取代导致的BDNF基因的常见单核苷酸多态性（SNP）与复杂的神经元表型相关，包括脑形态，脑内记忆或皮质的差异脑刺激后的可塑性，据信会影响机动学习任务后的突触变化。然而，这种多态性对脊柱塑性的影响仍然很大程度上是未知的。在这里，我们使用了阳极经皮脊柱直流刺激（TSDC），一种新型非侵入性技术，可在健康受试者中诱导脊神经元电路的可塑性。为了研究TSDCS对脊柱塑性探针的易感性是否受到BDNF多态性的显着影响，我们在TH11递送的阳极TSDCS（ 17个健康，15分钟，15分钟，0.071 mA / cm2和64 mc / cm2），符合年龄和性别的17型母载体和17个Val纯合。阳极TSDC在刺激期间诱导H反射过程中升级曲线的逐步向左转移，该刺激在Val / Val个体的当前偏移后至少15分钟。相反，在满足等位基因载体中未观察到这种转变。我们的研究结果首次证明了BDNF Val66met基因型的第一次会影响人类的脊柱塑性，如TSDC评估，可能是影响脊髓自然反应对损伤或疾病的一个因素。

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