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首页> 外文期刊>Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs >Carthamus red from Carthamus tinctorius L. exerts antioxidant and hepatoprotective effect against CCl4-induced liver damage in rats via the Nrf2 pathway
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Carthamus red from Carthamus tinctorius L. exerts antioxidant and hepatoprotective effect against CCl4-induced liver damage in rats via the Nrf2 pathway

机译：来自Carthamus Tinctorius L.通过NRF2途径施加抗氧化和肝脏损伤的抗氧化和肝脏药物损伤

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Ethnopharmacological relevance Carthamus red isolated from safflower (Carthamus tinctorius L., a Chinese traditional medicine) is evaluated for antioxidant and hepatoprotective activity. Materials and methods Carthamus red was isolated from a Na2CO3 extract of safflower and its analysis was carried out by HPLC/MS. Acute toxicity study was determined and the antioxidant activity was investigated using various established in vitro systems. An in vivo study against CCl4-induced liver injury was also conducted and compared with that of silymarin, a known hepatoprotective drug. Results Carthamus red did not show any toxicity and mortality up to 2000 mg/kg dose, and it showed strong antioxidant ability in vitro. In the in vivo study, carthamus red treatment lowered the serum levels of ALT, AST, ALP and total protein in liver damage rat models. Meanwhile, Nrf2, GSTα and NQO1 expressions were up-regulated at the protein level by carthamus red intervention. Additionally, the activities of antioxidant enzymes and level of GSH were elevated by carthamus red intervention, while the content of TBARS, which is an oxidative stress marker, was lessened. HE stain analysis showed that the condition of liver damage was mitigated. Conclusion This study demonstrates that carthamus red may serve as a candidate with strong a hepatoprotective effect and antioxidant activity in liver damage.
机译：从红花（Carthamus Tinctorius L.，中国传统医学）评估了抗氧化剂和肝脏保护活性的民族科医生相关卡车红色。材料和方法从红花的Na 2CO3提取物中分离出迦太基红斑，通过HPLC / MS进行分析。确定急性毒性研究，并使用各种成立的体外系统研究抗氧化活性。还对CCL4诱导的肝损伤进行了体内研究，并与Silymarin，一种已知的肝脏保护剂进行比较。结果迦太山红肿不显示毒性和死亡率高达2000 mg / kg剂量，并在体外显示出强烈的抗氧化能力。在体内研究中，迦太查红治疗降低了肝脏损伤大鼠模型中ALT，AST，ALP和总蛋白质的血清水平。同时，NRF2，GSTα和NQO1表达在蛋白质水平上由Carthamus红色干预上调。另外，抗氧化剂酶和GSH水平的活性通过迦太查红色干预升高，而TBAR的含量为氧化应激标记物。他染色分析表明，减轻了肝损伤的病症。结论本研究表明，红细胞红色可作为具有强烈肝脏损伤抗氧化反应效果和抗氧化活性的候选者。

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