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Optimal application time of lidocaine adhesive tape examined using current perception threshold measurement

机译：利用电流感知阈值测量检查利多卡因胶带的最佳应用时间

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BACKGROUND: We often use lidocaine adhesive tape (Penles, Wyeth Lederle Japan, Ltd., Tokyo, Japan) as a topical anesthetic prior to puncturing a vein with a needle. Since the tape is usually in place for a long time, we often experience problems with creasing and flaring when inserting the needle. We attempted to determine the optimal time for application of the tape as well as for vein puncture after its removal by measuring pain sensation in human subjects. METHODS: Lidocaine tape was applied to the dorsum of volunteer hands for 2, 4, 6, and 12 hours, and we evaluated changes after removal by determining current perception threshold (CPT), pain score, touch sensation score, diameter of the vein, pruritus, and flare. RESULTS: CPT levels were found to increase within 1 hour after removal of the lidocaine tape with all 3 electrical stimulus rates used (2000 Hz, 250 Hz, 5 Hz). Further, pain and touch sensation scores were low within 2 hours of removal regardless of application time. Notably, with 4 and 6hours of application, scores were stable 4 and 6 hours after removal. However, vein diameter and pruritis results did not change regardless of application time, while crease and flare were only observed within 30 minutes after removal. CONCLUSIONS: We concluded that lidocaine tape provided maximum pain relief when applied 4 to 6 hours prior to vein puncture and up to 1 hour after removal.
机译：背景：我们经常使用Lidocaine胶带（Penles，Wyeth Lederapea，Ltd，Tokyo，Japan）作为用针刺静脉刺穿静脉前的局部麻醉剂。由于胶带通常很长一段时间，我们经常在插入针时遇到褶皱和燃烧的问题。我们试图确定胶带应用的最佳时间以及通过测量人类受试者的疼痛感染后去除后静脉刺伤。方法：将Lidocaine胶带应用于志愿者手2,4,6和12小时，通过确定当前感知阈值（CPT），疼痛评分，触摸感测得分，静脉的直径来评估在去除后的变化。瘙痒和耀斑。结果：发现CPT水平在除去利多卡因胶带后1小时内增加（2000 Hz，250Hz，5 Hz）。此外，无论应用时间如何，疼痛和触摸感应分数低2小时内的2小时内。值得注意的是，用4和6小时的申请，分数在去除后4和6小时稳定。然而，无论应用时间如何，静脉直径和瘙痒结果都没有改变，而折痕和闪光仅在除去后30分钟内观察。结论：我们得出结论，利多卡内胶带在静脉刺穿前4至6小时施用时提供最大疼痛缓解，拆除后最多1小时。

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