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首页> 外文期刊>麻酔 >Sevoflurane can induce rhabdomyolysis in Duchenne's muscular dystrophy
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Sevoflurane can induce rhabdomyolysis in Duchenne's muscular dystrophy

机译：七氟醚可以诱导杜鹃肌营养不良症的横纹肌溶解

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摘要

Rhabdomyolysis is one of the perioperative complications in patients with Duchenne's muscular dystrophy (DMD). It has been suggested that sevoflurane can be used safely for anesthesia in patients with DMD. In this report, we describe a case with DMD who received anesthesia with sevoflurane, in which rhabdomyolysis developed postoperatively. A 6-year-old boy diagnosed as DMD was scheduled for tonsillectomy under general anesthesia. Preoperative laboratory examination revealed a high level of creatine kinase (CK) (16,000-32,000 IU.l-1). An abnormality of the dystrophin gene was detected by DNA analysis. Anesthesia was induced with sevoflurane without muscle relaxant, and maintained with sevoflurane in nitrous oxide and oxygen under controlled ventilation. The course of anesthesia was uneventful and the patient recovered smoothly. Three hours postoperatively, dark red urine with a high concentration of myoglobin (1,390,000 ng.ml-1) was recognized with a high level of CK (63,500 IU.l-1). Body temperature was 37.6 degrees C, and electrocardiogram and serum potassium were within normal ranges. After the diuresis with mannitol and furosemide, the urine became clear. On the 4th postoperative day, he was discharged without any complication. This case suggested that rhabdomyolysis can develop after sevoflurane anesthesia in patients with DMD.
机译：横纹肌溶解是杜鹃患者肌营养不良症（DMD）的围手术期并发症之一。已经提出，七氟醚可以安全地用于DMD患者的麻醉。在本报告中，我们描述了DMD接受了与七氟烷麻醉的案例，在术后开发的纹状体溶解。在全身麻醉下，诊断为DMD的一个6岁的男孩被安排用于扁桃体切除术。术前实验室检查显示出高水平的肌酸激酶（CK）（16,000-32,000 Iu.L-1）。通过DNA分析检测营养不良蛋白基因的异常。在没有肌肉松弛剂的情况下用七氟醚诱导麻醉，并在受控通气中以氧化亚氮和氧气保持七氟醚。麻醉过程不合适，患者顺利恢复。术后三个小时，具有高浓度的肌红蛋白（1,390,000ng.ml-1）的深红尿液，具有高水平的CK（63,500 Iu.L-1）。体温为37.6℃，心电图和血清钾在正常范围内。在甘露醇和呋塞米的利尿后，尿液变得清晰。在术后第四天，他被出院而没有任何并发​​症。这种情况表明，在DMD患者的七氟醚麻醉后横纹肌溶解可以发生。

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