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首页> 外文期刊>麻酔 >Prolonged paralysis after long-term administration of vecuronium in the intensive care unit
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Prolonged paralysis after long-term administration of vecuronium in the intensive care unit

机译：长期施用脉络膜后长期瘫痪的重症监护单位

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A 51-year-old woman with renal failure requring hemodialysis received a total of 446 mg of vecuronium over a period of 4 days to help mechanical ventilation and developed generalized muscle weakness after its discontinuation. It took 2 wks to wean her from mechanical ventilation and 3 wks for her to be able to walk. She did not receive drugs which might alter neuromuscular transmission such as corticosteroid and aminoglycoside antibiotics. Electromyogram and nerve conduction studies were normal. We believe that the cause is the accumulation of vecuronium and active metabolites due to renal failure. The case suggests that we should minimize the duration of neuromuscular block in patients with renal failure by aggressive use of sedatives and analgesics and the optimization of ventilator settings.
机译：一个51岁的女性，肾功能衰竭试验血液透析在4天内获得了446毫克的脉尼，以帮助机械通气，在停止后发育广泛的肌肉无力。 从机械通风和3个WKS供她走路需要2个WKS才能走路。 她没有收到可能改变神经肌肉传播的药物，如皮质类固醇和氨基糖苷类抗生素。 电灰度和神经传导研究是正常的。 我们认为，由于肾功能衰竭，原因是葡萄孢和活性代谢物的积累。 案例表明，通过积极使用镇静剂和镇痛药以及呼吸机环境的优化，我们应该最大限度地减少肾功能衰竭患者的神经肌肉嵌段的持续时间。

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