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首页> 外文期刊>Acta biomaterialia >Synthesis of biomimetic segmented polyurethanes as antifouling biomaterials
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Synthesis of biomimetic segmented polyurethanes as antifouling biomaterials

机译：仿生链段聚氨酯作为防污生物材料的合成

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Controlling the non-specific adsorption of proteins, cells and bacteria onto biomaterial surfaces is of crucial importance for the development of medical devices with specific levels of performance. Among the strategies pursued to control the interactions between material surfaces and biological tissues, the immobilization of non-fouling polymers on biomaterial surfaces as well as the synthesis of the so-called biomimetic polymers are considered promising approaches to elicit specific cellular responses. In this study, in order to obtain materials able to prevent infectious and thrombotic complications related to the use of blood-contacting medical devices, heparin-mimetic segmented polyurethanes were synthesized and fully characterized. Specifically, sulfate or sulfamate groups, known to be responsible for the biological activity of heparin, were introduced into the side chain of a carboxylated polyurethane. Due to the introduction of these groups, the obtained polymers possessed a higher hard/soft phase segregation (lower glass transition temperatures) and a greater hydrophilicity than the pristine polymer. In addition, the synthesized polymers were able to significantly delay the activated partial thromboplastin time, this increased hemocompatibility being related both to polymer hydrophilicity and to the presence of the -SO 3H groups. This last feature was also responsible for the ability of these biomimetic polymers to prevent the adhesion of a strain of Staphylococcus epidermidis.
机译：控制蛋白质，细胞和细菌在生物材料表面上的非特异性吸附对于开发具有特定性能水平的医疗器械至关重要。在控制材料表面和生物组织之间相互作用的策略中，将不结垢的聚合物固定在生物材料表面上以及所谓的仿生聚合物的合成被认为是引发特定细胞反应的有前途的方法。在这项研究中，为了获得能够预防与使用接触血液的医疗设备相关的传染性和血栓性并发症的材料，合成了肝素模拟分段聚氨酯并对其进行了充分表征。具体地，将已知负责肝素生物活性的硫酸根或氨基磺酸根基团引入羧化聚氨酯的侧链中。由于这些基团的引入，所获得的聚合物比原始聚合物具有更高的硬/软相偏析（更低的玻璃化转变温度）和更高的亲水性。另外，合成的聚合物能够显着延迟活化的部分凝血活酶时间，这种增加的血液相容性与聚合物亲水性和-SO 3H基团的存在有关。最后一个特征还负责这些仿生聚合物防止表皮葡萄球菌菌株粘附的能力。

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