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首页> 外文期刊>Acta biomaterialia >Tailoring the morphology of high molecular weight PLLA scaffolds through bioglass addition.
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Tailoring the morphology of high molecular weight PLLA scaffolds through bioglass addition.

机译：通过生物玻璃添加量身定制高分子量PLLA支架的形态。

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摘要

Thermally induced phase separation (TIPS) has proven to be a suitable method for the preparation of porous structures for tissue engineering applications, and particular attention has been paid to increasing the pore size without the use of possible toxic surfactants. Within this context, an alternative method to control the porosity of polymeric scaffolds via the combination with a bioglass is proposed in this work. The addition of a bioactive glass from the 3CaO x P2O5-MgO-SiO2 system enables the porous structure of high molecular weight poly(l-lactic) acid (PLLA) scaffolds prepared by TIPS to be tailored. Bioglass acts as a nucleating catalyst agent of the PLLA matrix, promoting its crystallization, and the glass solubility controls the pore size. A significant increase in the pore size is observed as the bioglass content increases and scaffolds with large pore size (approximately 150 microm) can be prepared. In addition, the bioactive character of the scaffolds is proved by in vitro tests in synthetic plasma. The importance of this approach resides on the combination of the ability to tailor the porosity of polymeric scaffolds via the tunable solubility of bioglasses, without the use of toxic surfactants, leading to a composite structure with suitable properties for bone tissue engineering applications.
机译：热致相分离（TIPS）已被证明是制备用于组织工程应用的多孔结构的合适方法，并且特别注意了在不使用可能的有毒表面活性剂的情况下增加孔径的问题。在此背景下，在这项工作中提出了一种通过与生物玻璃结合来控制聚合物支架孔隙率的替代方法。通过从3CaO x P2O5-MgO-SiO2系统中添加生物活性玻璃，可以定制TIPS制备的高分子量聚（乳酸）骨架（PLLA）的多孔结构。生物玻璃充当PLLA基质的成核催化剂，促进其结晶，玻璃溶解度控制孔径。随着生物玻璃含量的增加，可以观察到孔径的显着增加，并且可以制备具有大孔径（约150微米）的支架。另外，通过在合成血浆中的体外测试证明了支架的生物活性特征。这种方法的重要性在于结合生物玻璃可调节的溶解度来调节聚合物支架孔隙率的能力的组合，而无需使用有毒的表面活性剂，从而形成具有适合骨组织工程应用性质的复合结构。

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