Cu(I)-catalyzed double C-H amination: synthesis of 2-iodo-imidazo[1,2-a]pyridines

Dheer Divya; Reddy K. Ranjith; Rath Santosh K.; Sangwan P. L.; Das Parthasarthi; Shankar Ravi

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Cu(I)-catalyzed double C-H amination: synthesis of 2-iodo-imidazo[1,2-a]pyridines

机译：Cu（I） - 催化双C-H胺化：合成2-Iodo-咪唑[1,2-A]吡啶

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An iodine/CuI mediated double oxidative C-H amination reaction has been developed for the synthesis of 2-iodo-imidazo[1,2-a]pyridines. The salient features of this methodology are mild reaction conditions and high regioselectivity. The designed compounds e.g. 2-iodo-imidazo[1,2-a]pyridines (3e) may serve as active pharmaceutical ingredients (APIs) of marketed drugs like saripidem and nicopidem. Further saripidem was synthesised by using 3e as an intermediate.

机译：已经开发了碘/ Cui介导的双氧化C-H胺化反应，用于合成2-Iodo-Imidazo [1,2-A]吡啶。该方法的显着特征是温和的反应条件和高区域选择性。设计的化合物例如。 2-碘 - 咪唑[1,2-a]吡啶（3e）可以作为令人兴趣的葡萄酒和尼科米的销售药物的活性药物成分（API）。通过使用3E作为中间体合成了另外的Saripidem。

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来源
《RSC Advances》 |2016年第44期|共4页
作者
Dheer Divya; Reddy K. Ranjith; Rath Santosh K.; Sangwan P. L.; Das Parthasarthi; Shankar Ravi;
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Acad Sci &

Innovat Res AcSIR Jammu Campus Hyderabad Andhra Pradesh India;

Acad Sci &

Innovat Res AcSIR Jammu Campus Hyderabad Andhra Pradesh India;

Acad Sci &

Innovat Res AcSIR Jammu Campus Hyderabad Andhra Pradesh India;

Acad Sci &

Innovat Res AcSIR Jammu Campus Hyderabad Andhra Pradesh India;

Acad Sci &

Innovat Res AcSIR Jammu Campus Hyderabad Andhra Pradesh India;

Acad Sci &

Innovat Res AcSIR Jammu Campus Hyderabad Andhra Pradesh India;

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正文语种 eng
中图分类化学;
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1. Cu(I)-catalyzed double C-H amination: synthesis of 2-iodo-imidazo[1,2-a]pyridines (vol 6, pg 38033, 2016) [J] . Dheer Divya u, Reddy K. Ranjith, Rath Santosh K., RSC Advances . 2017,第64期

机译：Cu（I） - 催化双C-H胺化：合成2-Iodo-咪唑[1,2-A]吡啶（Vol 6，Pg 38033,2016）
2. Copper-catalyzed intramolecular oxidative amination of enaminone C-H bond for the synthesis of imidazo[1,2-a]pyridines [J] . Wan Jie-Ping, Hu Deqing, Liu Ying, Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2016,第26期

机译：铜催化的烯胺酮C-H键分子内氧化胺化反应合成咪唑并[1,2-a]吡啶
3. Synthesis of naphtho[1 ',2 ':4,5]imidazo[1,2-a]pyridines via Rh(iii)-catalyzed C-H functionalization of 2-arylimidazo[1,2-a]pyridines with cyclic 2-diazo-1,3-diketones featuring with a ring opening and reannulation [J] . Organic Chemistry Frontiers . 2020,第7期

机译：通过RH（III）的萘酚[1'，2'：4,5]咪唑吡啶（III） - 催化2-芳基咪唑的CH官能化，其具有环状2-重氮的吡啶 1,3-diketones采用环形开口和恢复
4. Synthesis of Helicenes Utilizing Palladium-Catalyzed Double C-H Arylation Reaction [C] . Ken Kamikawa, Ippei Takemoto, Shin Takemoto Symposium on Organometallic Chemistry . 2007

机译：利用钯催化的双C-H芳基化反应的螺旋合成
5. Copper-catalyzed functionalization of alkenes: Carboamination, C-H amination, C-H alkylation and carboetherifcation reactions. [D] . Liwosz, Timothy Walter. 2014

机译：铜催化烯烃的官能化：碳氨基化，C-H氨基化，C-H烷基化和碳醚化反应。
6. A Cu(I)-Catalyzed C-H α-Amination of Aryl Ketones. Direct Synthesis of Imidazolinones [O] . Baoguo Zhao, Haifeng Du, Yian Shi -1

机译：甲的Cu（I）催化C-H芳酮的α胺化。咪唑啉酮的直接合成
7. Correction: Cu(i)-catalyzed double C–H amination: synthesis of 2-iodo-imidazo1,2-apyridines [O] . Divya Dheer, K. Ranjith Reddy, Santosh K. Rath, 2017

机译：校正：Cu（I） - 催化双C-H胺化：合成2-Iodo-咪唑1,2-A吡啶

Cu(I)-catalyzed double C-H amination: synthesis of 2-iodo-imidazo[1,2-a]pyridines

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