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首页> 外文期刊>Biochemical Genetics >Insertion/deletion polymorphism and serum activity of the angiotensin-converting enzyme in Turkish patients with obstructive sleep apnea syndrome.
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Insertion/deletion polymorphism and serum activity of the angiotensin-converting enzyme in Turkish patients with obstructive sleep apnea syndrome.

机译：阻塞性睡眠呼吸暂停综合征的土耳其患者血管紧张素转化酶的插入/缺失多态性和血清活性。

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摘要

This study determined the allelic frequency and genotypic distribution of an angiotensin-converting enzyme (ACE) polymorphism and serum ACE activity in Turkish patients with obstructive sleep apnea syndrome (OSAS). A colorimetric assay measured serum ACE activity in 73 of 97 subjects. Frequencies for II, ID, and DD genotypes were 19.6, 53.6, and 26.8% in the OSAS group and 15, 38, and 47% in the control group, respectively (P = 0.02). The I allele frequency was higher in the OSAS group than in the healthy control group (P = 0.02). Carrying the I allele (II or ID genotypes) increased OSAS risk 2.41 times in the Turkish population. Mean ACE activity was significantly lower in patients with the II genotype than in the DD genotype (P = 0.011), and ACE activity was significantly lower in patients with severe OSAS than in those with mild OSAS (P = 0.006). Our results suggest that II and ID genotypes of the ACE gene increase the risk of developing OSAS in the Turkish population.
机译：该研究确定了土耳其患者阻塞呼吸暂停综合征（OSAS）的血管紧张素转换酶（ACE）多态性（ACE）多态性和血清ACE活性的等位基因频率和基因型分布。 比色测定测量97个受试者的73例血清ACE活性。 II，ID和DD基因型的频率分别为19.6,53.6和26.8％，分别在对照组中的15,38％和47％（P = 0.02）。 OSAS组的I等位基因频率高于健康对照组（P = 0.02）。 携带I等位基因（II或ID基因型）增加了土耳其人口2.41次的欧洲风险。 II基因型患者的平均ACE活性比在DD基因型（P = 0.011）中的患者显着降低，并且严重OSAs的患者中的ACE活性显着降低，而不是轻度OSA的患者（p = 0.006）。 我们的研究结果表明，ACE基因的II和ID基因型增加了土耳其人口中发展奥斯塔斯的风险。

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