alpha B-Crystallin Phosphorylation: Advances and Problems

Muranova L. K.; Sudnitsyna M. V.; Gusev N. B.

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alpha B-Crystallin Phosphorylation: Advances and Problems

机译：αB晶型磷酸化：进步和问题

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The review is dedicated to phosphorylation of alpha B-crystallin (HspB5), one of ubiquitously expressed small heat shock proteins. We describe the structure and properties of alpha B-crystallin and protein kinases involved in its phosphorylation in different cells and tissues, advantages and drawbacks of pseudophosphorylation mutants in elucidation of the mechanism of alpha B-crystallin functioning, effects of phosphorylation on the quaternary structure and intracellular location of alpha B-crystallin, interactions of alpha B-crystallin with different elements of the cytoskeleton, and effect of phosphorylation on the chap-erone-like activity of alpha B-crystallin. We also discuss the validity of experimental data obtained by overexpression of pseudophosphorylation mutants for understanding the effect of phosphorylation on physiologically important properties of alpha B-crystallin, as well as the question why multiple attempts to phosphorylate alpha B-crystallin in vitro have been unsuccessful so far.

机译：审查专用于αb晶体（Hspb5）的磷酸化，普遍地表达的小型热休克蛋白之一。我们描述了αb晶体和蛋白激酶的结构和性质，其磷酸化在不同的细胞和组织中，假磷酸化突变体的优点和缺点阐明了αb晶体功能的机理，磷酸化对季结构的影响αb结晶素的细胞内位置，αb晶体与细胞骨架不同元素的相互作用，以及磷酸化对αb晶体的β-晶样活性的影响。我们还讨论了通过过表达对假磷酸化突变体获得的实验数据的有效性，以了解磷酸化对αb结晶的生理学上重要性质的影响，以及为什么多次尝试在体外磷酸化αB-结晶素的多次尝试已经不成功远的。

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《Biochemistry》 |2018年第10期|共11页
作者
Muranova L. K.; Sudnitsyna M. V.; Gusev N. B.;
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作者单位

Lomonosov Moscow State Univ Fac Biol Moscow 119991 Russia;

Lomonosov Moscow State Univ Fac Biol Moscow 119991 Russia;

Lomonosov Moscow State Univ Fac Biol Moscow 119991 Russia;

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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
small heat shock proteins; crystallins; phosphorylation; protein kinases;

机译：小型热休克蛋白;晶体;磷酸化;蛋白激酶;

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专利

1. Effect of phosphorylation on alpha B-crystallin: Differences in stability, subunit exchange and chaperone activity of homo and mixed oligomers of alpha B-crystallin and its phosphorylation-mimicking mutant [J] . Ahmad MF, Raman B, Ramakrishna T, Journal of Molecular Biology . 2008,第4期

机译：磷酸化对αB-晶状蛋白的影响：αB-晶状蛋白及其模拟磷酸化突变体的同或混合低聚物的稳定性，亚基交换和分子伴侣活性的差异
2. Regulation of alpha A- and alpha B-crystallins via phosphorylation in cellular homeostasis [J] . Thornell Erin, Aquilina Andrew Cellular and molecular life sciences: CMLS . 2015,第21期

机译：通过细胞稳态中的磷酸化调节αA和αB晶状体蛋白
3. Phosphorylations of alpha A- and alpha B-crystallin [J] . Kantorow M., Piatigorsky J. International Journal of Biological Macromolecules: Structure, Function and Interactions . 1998,第3a4期

机译：αA-和αB-晶状体蛋白的磷酸化
4. PROPOSAL OF A NEW COUNTERMEASURE FOR RED MUSCLE ATROPHY IN SPACE AND AGED PEOPLE: A KEY MOLECULAR CHAPERONE ALPHA B-CRYSTALLIN AS A PIVOTAL PLAYER FOR CELLULAR SUSTAINABLE DYNAMICS [C] . Yoriko Atomi, Eri Ohoto-Fujita, Miho Shimizu, IAC;International Astronautical Congress . 2012

机译：关于在空间和老年人中红色肌肉萎缩的新对策的建议：关键分子伴侣αB-Crystallin作为细胞可持续动力学的重要角色
5. Control of Mitochondrial αB-crystallin Function by Phosphorylation [D] . Posada, Angie 2018

机译：磷酸化控制线粒体αB-晶体蛋白功能
6. The murine alpha B-crystallin/small heat shock protein enhancer: identification of alpha BE-1 alpha BE-2 alpha BE-3 and MRF control elements. [O] . R Gopal-Srivastava, J Piatigorsky 1993

机译：鼠类αB-晶状蛋白/小热激蛋白增强剂：鉴定αBE-1αBE-2αBE-3和MRF控制元件。
7. Monitoring the Interaction between beta(2)-Microglobulin and the Molecular Chaperone alpha B-crystallin by NMR and Mass Spectrometry: alpha B-CRYSTALLIN DISSOCIATES beta(2)-MICROGLOBULIN OLIGOMERS [O] . Esposito, G, Garvey, M, Alverdi, V, 2013

机译：通过NMR和质谱监测β（2）-微球蛋白和分子伴侣αB-晶状蛋白之间的相互作用：αB-结晶酪蛋白分解β（2）-微球蛋白寡聚体

alpha B-Crystallin Phosphorylation: Advances and Problems

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