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Studies of the Process of Amyloid Formation by A beta Peptide

机译：β肽淀粉样蛋白形成方法的研究

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Studies of the process of amyloid formation by A beta peptide have been topical due to the critical role of this peptide in the pathogenesis of Alzheimer's disease. Many articles devoted to this process are available in the literature; however, none of them gives a detailed description of the mechanism of the process of generation of amyloids. Moreover, there are no reliable data on the influence of modified forms of A beta peptide on its amyloid formation. To appreciate the role of A beta aggregation in the pathogenesis of Alzheimer's disease and to develop a strategy for its treatment, it is necessary to have a well-defined description of the molecular mechanism underlying the formation of amyloids as well as the contribution of each intermediate to this process. We are convinced that a combined analysis of theoretical and experimental methods is a way for understanding molecular mechanisms of numerous diseases. Based on our experimental data and molecular modeling, we have constructed a general model of the process of amyloid formation by A beta peptide. Using the data described in our previous publications, we propose a model of amyloid formation by this peptide that differs from the generally accepted model. Our model can be applied to other proteins and peptides as well. According to this model, the main building unit for the formation of amyloid fibrils is a ring-like oligomer. Upon interaction with each other, ring-like oligomers form long fibrils of different morphology. This mechanism of generation of amyloid fibrils may be common for other proteins and peptides.
机译：由于这种肽在阿尔茨海默病的发病机制中的关键作用，β肽的淀粉样蛋白形成方法的研究是局部。文献中有许多致力于该过程的文章;然而，它们没有任何一种描述淀粉样蛋白的产生方法的详细描述。此外，没有关于β肽的改性形式对其淀粉样蛋白形成的影响的可靠数据。为了欣赏β聚集在阿尔茨海默病的发病机制中的作用，以及制定其治疗策略的作用，有必要具有明确定义的对淀粉样蛋白形成的分子机制的描述以及每个中间体的贡献这个过程。我们相信，对理论和实验方法的综合分析是理解众多疾病的分子机制的一种方式。基于我们的实验数据和分子建模，我们通过β肽构建了淀粉样蛋白形成方法的一般模型。使用我们以前的出版物中描述的数据，我们提出了由该肽不同于普遍接受的模型的淀粉样蛋白形成模型。我们的模型也可以应用于其他蛋白质和肽。根据该模型，用于形成淀粉样蛋白原纤维的主建筑单元是环状低聚物。在相互作用时，环状低聚物形成不同形态的长纤维。这种产生淀粉样蛋白原纤维的机制可能是其他蛋白质和肽的常见。

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