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首页> 外文期刊>Biomaterials Science >Nanoparticle size and chemical modification play a crucial role in the interaction of nano gold with the brain: extent of accumulation and toxicity
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Nanoparticle size and chemical modification play a crucial role in the interaction of nano gold with the brain: extent of accumulation and toxicity

机译：纳米粒子尺寸和化学改性在纳米金与大脑的相互作用中起着至关重要的作用：积累和毒性的程度

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The blood brain barrier (BBB) is a very selective barrier that protects the brain and the central nervous system (CNS) from the entry of harmful substances and helps regulate the exchange of different molecules and nutrients from and into the brain and the CNS. This selectivity makes delivering therapeutic and diagnostic materials across the BBB very challenging. In this study, different shapes and sizes of gold nanoparticles (GNP) were synthesized and functionalized with five different thiolated ligands to obtain GNP with various surface chemistries. The potential of GNP of different properties to be accumulated into the brain through the BBB and into other organs was investigated in a mouse model using qualitative and quantitative approaches. Gold nanorods (GNR) functionalized with 4-mercaptophenol (Mph) showed the highest penetration ability across the BBB into the brain with no significant deposition in other organs. Interestingly, increasing the size of GNR retarded their delivery into the brain, while enhancing their accumulation in other organs. On the other hand, gold nanospheres (GNS) demonstrated high deposition percentages in the brain and other organs with possible toxic effects. The properties of GNP play a crucial role in their interaction with the BBB and accumulation in the brain and other organs. Thus, GNP can be considered a promising nano-platform for drug delivery into the brain and as a photothermal-inducing agent against brain cancer.
机译：血脑屏障（BBB）是一种非常选择的屏障，可保护大脑和中枢神经系统（CNS）免受有害物质的进入，有助于调节不同分子和营养物的交换，进入脑和CNS。这种选择性使得在BBB中提供治疗性和诊断材料非常具有挑战性。在该研究中，用五种不同的硫化配体合成和官能化的金纳米颗粒（GNP）的不同形状和大小，得到各种表面化学物质的GNP。使用定性和定量方法在小鼠模型中研究了通过BBB积聚到脑中的不同性质的GNP与脑中的电位。用4-巯基苯酚（MPH）官能化的金纳米棒（GNR）在其他器官中显示出BBB的最高渗透能力，在其他器官中没有显着沉积。有趣的是，增加了GNR的大小延迟了他们的递送到大脑中，同时提高其其他器官的积累。另一方面，金纳米球（GNS）在脑和其他器官中显示出高沉积百分比，具有可能的毒性作用。 GNP的性质在与BBB的相互作用中起着至关重要的作用，并在大脑和其他器官中积累。因此，GNP可以被认为是一种有望的纳米平台，用于药物输送到脑中，作为针对脑癌的光热诱导剂。

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