• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biochemistry and Cell Biology >Human telomerase expression regulation.
【24h】

Human telomerase expression regulation.

机译：人端粒酶表达调节。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Since telomerase has been recognized as a relevant factor distinguishing cancer cells from normal cells, it has become a very promising target for anti-cancer therapy. A correlation between short telomere length and increased mortality was revealed in many studies. The telomerase expression/activity appears to be one of the most crucial factors to study to improve cancer therapy and prevention. However, this multisubunit enzymatic complex can be regulated at various levels. Thus, several strategies have been proposed to control telomerase in cancer cells such as anti-sense technology against TR and TERT, ribozymes against TERT, anti-estrogens, progesterone, vitamin D, retinoic acid, quadruplex stabilizers, telomere and telomerase targeting agents, modulation of interaction with other proteins involved in the regulation of telomerase and telomeres, etc. However, the transcription control of key telomerase subunits seems to play the crucial role in whole complexes activity and cancer cells immortality. Thus, the research of telomerase regulation can bring significant insight into the knowledge concerning stem cells metabolism but also ageing. This review summarizes the current state of knowledge of numerous telomerase regulation mechanisms at the transcription level in human that might become attractive anti-cancer therapy targets.
机译：由于端粒酶被认为是区分癌细胞与正常细胞的相关因子，因此它已成为抗癌治疗的非常有前景的靶标。许多研究中揭示了短端粒长度和增加的死亡率之间的相关性。端粒酶表达/活性似乎是改善癌症治疗和预防的最重要因素之一。然而，这种多相酶酶络合物可以在各种水平下调节。因此，已经提出了几种策略来控制癌细胞中的端粒酶，例如反感技术免受TR和TERT，核苷，抗脱发，孕酮，维生素D，视黄酸，四驱稳定剂，端粒和端粒酶靶向剂，调制然而，与涉及端粒酶和端粒调节的其他蛋白质的相互作用，关键端粒酶亚基的转录控制似乎在整个复合体活性和癌细胞不朽中发挥着至关重要的作用。因此，端粒酶调节的研究可以对有关干细胞代谢而且老化的知识进行显着洞察。本综述总结了人类转录水平的许多端粒酶调控机制的当前知识状态，这可能成为有吸引力的抗癌治疗目标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号