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首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >Surface induced collapse of Abeta_(1-42) with the F19A replacement following adsorption on a single walled carbon nanotube
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Surface induced collapse of Abeta_(1-42) with the F19A replacement following adsorption on a single walled carbon nanotube

机译：表面诱导的ABETA_（1-42）的崩溃，在一个壁碳纳米管上吸附后的F19a替代品

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摘要

Spontaneous adsorption of the Abeta peptide on the surface of a single-walled carbon nanotube, resulting in the prevention of its intrinsic propensity to form collapsed states, could be a plausible means to hinder the peptide's initial nucleation and self-assembly. We report here the effects of sharply reducing both aromatic and hydrophobic character within the peptide's central hydrophobic core on its free and surface behavior. In such an altered pep-tide, complete surface adsorption is found to induce, rather than prevent, the adsorbed peptide's collapse. The weakened surface interactions of the central hydrophobic core allow its greater translational mobility on the surface, thereby facilitating interactions that lead to compaction. Both the adsorption and the subsequent collapse are accompanied by a loss of surface hydration in the modified peptide. We further find that such a two-step dewetting leads to hydration levels comparable to that obtained after compaction of the free peptide. These insights may be leveraged for designing molecular surfaces for disrupting intrinsic Abeta behavior.
机译：Abeta肽在单壁碳纳米管表面上的自发吸附，导致预防其固有的形成塌陷状态的倾向，可能是妨碍肽的初始成核和自组装的合理手段。我们在此报告了在其自由和表面行为上急剧减少肽中的芳族和疏水性质的影响。在这种改变的薄膜潮中，发现完全吸附诱导，而不是预防，吸附的肽的塌陷。中央疏水芯的弱化表面相互作用允许其在表面上更大的平移迁移率，从而促进导致压实的相互作用。吸附和随后的塌陷均伴随着改性肽中的表面水化损失。我们进一步发现，这样的两步脱水导致与游离肽压实后获得的水合水平相当。可以利用这些见解来设计用于破坏内在的ABETA行为的分子表面。

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