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Interferon signaling in the liver during hepatitis C virus infection

机译:丙型肝炎病毒感染期间肝脏中的干扰素信号传导

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摘要

Hepatitis C virus is a global health concern, estimated to infect 2-3% of the world's population. Inter-individual differences in the course of infection and response to therapy, highlighted by recent genomewide association studies, point to the crucial role of the host immune system in the efficient control of infection. Ongoing progress in the studies of the role of innate immunity during hepatitis C virus infection has improved our understanding of the intricacies of the host-virus interactions. In this review, we summarize and discuss the current knowledge concerning interferon signaling in the liver during acute and chronic hepatitis C virus infection and its implications for the outcome of interferon-α-based antiviral therapies.
机译:丙型肝炎病毒是全球性的健康问题,估计感染了全球2-3%的人口。最近的全基因组关联研究强调了感染过程和治疗反应之间的个体差异,指出宿主免疫系统在有效控制感染中的关键作用。关于固有免疫在丙型肝炎病毒感染过程中的作用的研究的不断进展,提高了我们对宿主-病毒相互作用的复杂性的理解。在这篇综述中,我们总结和讨论了有关急性和慢性丙型肝炎病毒感染期间肝脏中干扰素信号转导的最新知识及其对基于干扰素-α的抗病毒疗法的结果的影响。

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