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首页> 外文期刊>Brain injury: BI >Cytotoxicity of titanium dioxide nanoparticles in rat neuroglia cells
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Cytotoxicity of titanium dioxide nanoparticles in rat neuroglia cells

机译：大鼠神经节细胞中二氧化钛纳米颗粒的细胞毒性

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摘要

Aim: To find the cytotoxicity of titanium dioxide nanoparticles (nano-TiO2) posed to neuroglia cells. Methods: This study tested the inhibiting effect of different sized nano-TiO2 on the cell survival rate for rat astrocytes in vitro and in vivo and pathological analysis was also done to evaluate its effect; IL-1β, TNF-α and IL-10 of rat brain tissue was also examined. Results: In vitro examination, the inhibiting effect of nano-TiO2 on the cell survival rate, was significantly enhanced dose dependently. There were also obvious changes in cellular configuration, such as sparse arrangement, increscent cell spaces, increasing intracellular particles and decreasing cellular transparency. When rats were exposed to nano-TiO2 of 10 and 20 nm in diameter in 1.0 and 10.0 mg kg-1, the concentrations IL-1β, TNF-α and IL-10 in brain tissue increased with the dose of nano-TiO2. Pathological observation indicated that the blood-brain barrier was destroyed and resulted in brain tissue necrosis, inflammation and cellular oedema. Conclusions: Nano-TiO2 is toxic to rat neuroglia cells. This toxicity may be related to particle size and the mechanism may be associated with its induction inflammation.
机译：目的：发现二氧化钛纳米颗粒（Nano-TiO2）呈神经节细胞的细胞毒性。方法：本研究检测了不同大小纳米TiO2对大鼠星形胶质细胞体外细胞存活率的抑制作用，并且还进行了病理分析来评估其效果;还检查了大鼠脑组织的IL-1β，TNF-α和IL-10。结果：体外检测，纳米TiO2对细胞存活率的抑制作用，依赖性增强剂量显着增强。细胞构造也有明显的变化，例如稀疏布置，鳞片状细胞空间，增加细胞内颗粒并降低细胞透明度。当大鼠暴露于直径为1.0和10.0mg KG-1的直径为10和20nm的纳米TiO 2时，脑组织中浓度IL-1β，TNF-α和IL-10随纳米TiO2的剂量增加。病理观察表明，血脑屏障被破坏并导致脑组织坏死，炎症和细胞水肿。结论：纳米TiO2对大鼠神经节细胞有毒。这种毒性可能与粒径有关，并且机制可以与其诱导炎症有关。

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