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首页> 外文期刊>British Journal of Haematology >Nodular lymphocyte predominant Hodgkin lymphoma in children and adolescents - a comprehensive review of biology, clinical course and treatment options
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Nodular lymphocyte predominant Hodgkin lymphoma in children and adolescents - a comprehensive review of biology, clinical course and treatment options

机译：儿童和青少年的结节性淋巴细胞主要霍奇金淋巴瘤 - 全面审查生物学，临床课程和治疗方案

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摘要

Nodular lymphocyte predominant Hodgkin lymphoma (nLPHL) is a unique variant of Hodgkin lymphoma with an overall good prognosis. It is conspicuously different from classical Hodgkin lymphoma (cHL) and is now recognized as distinctive form of B cell lymphoma. Although it has an indolent clinical course, it has a propensity for multiple and often late relapses. Although the majority of children present with early stage disease and without B symptoms, treatment strategy has, until recently, been identical to that used for cHL. This approach is excessively toxic as it predisposes these children and adolescents to serious late effects including end organ damage to heart, gonads, lungs, thyroid and second malignant neoplasms. The aim of this article is to review the published literature on the treatment outcomes of nLPHL in affected children and adolescents, and discuss the options for treatment including surgery, chemotherapy, radiotherapy and targeted anti-CD 20 antibody therapy.
机译：结节淋巴细胞主要霍奇金淋巴瘤（Nlphl）是一种独特的霍奇金淋巴瘤变体，具有良好的预后。 它与古典霍奇金淋巴瘤（CHL）显着不同，现在被认为是B细胞淋巴瘤的独特形式。 虽然它具有惰性的临床课程，但它具有多倍和经常延迟复发的倾向。 虽然大多数儿童存在早期疾病和没有B症状的患儿，但迄今为止，治疗策略与用于CHL相同。 这种方法是过于毒性，因为它使这些儿童和青少年倾向于严重的晚期效果，包括心脏，性腺，肺，甲状腺和第二恶性肿瘤和第二恶性肿瘤的最终器官损伤。 本文的目的是审查受影响儿童和青少年Nlphl治疗结果的发表的文献，并讨论治疗方案，包括手术，化疗，放疗和靶向抗CD 20抗体治疗。

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