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Innate immune response to viral infection.

机译:对病毒感染的先天免疫反应。

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摘要

In viral infections the host innate immune system is meant to act as a first line defense to prevent viral invasion or replication before more specific protection by the adaptive immune system is generated. In the innate immune response, pattern recognition receptors (PRRs) are engaged to detect specific viral components such as viral RNA or DNA or viral intermediate products and to induce type I interferons (IFNs) and other pro-inflammatory cytokines in the infected cells and other immune cells. Recently these innate immune receptors and their unique downstream pathways have been identified. Here, we summarize their roles in the innate immune response to virus infection, discrimination between self and viral nucleic acids and inhibition by virulent factors and provide some recent advances in the coordination between innate and adaptive immune activation.
机译:在病毒感染中,宿主先天性免疫系统旨在作为一线防御,在产生适应性免疫系统的更具体保护之前,防止病毒入侵或复制。在先天免疫应答中,模式识别受体(PRR)参与检测特定的病毒成分,例如病毒RNA或DNA或病毒中间产物,并在感染的细胞和其他细胞中诱导I型干扰素(IFN)和其他促炎性细胞因子。免疫细胞。最近,已经确定了这些先天免疫受体及其独特的下游途径。在这里,我们总结了它们在对病毒感染的先天免疫应答,对自身和病毒核酸的区分以及对强毒因子的抑制中的作用,并提供了在先天与适应性免疫激活之间的协调方面的一些最新进展。

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