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Transcriptional and post-translational regulation of pannexins

机译：Pannexins的转录和翻译后调节

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Abstract Pannexins are a 3-membered family of proteins that form large pore ion and metabolite channels in vertebrates. The impact of pannexins on vertebrate biology is intricately tied to where and when they are expressed, and how they are modified, once produced. The purpose of this review is therefore to outline our current understanding of transcriptional and post-translational regulation of pannexins. First, we briefly summarize their discovery and characteristics. Next, we describe several aspects of transcriptional regulation, including cell and tissue-specific expression, dynamic expression over development and disease, as well as new insights into the underlying molecular machinery involved. Following this, we delve into the role of post-translational modifications in the regulation of trafficking and channel properties, highlighting important work on glycosylation, phosphorylation, S-nitrosylation and proteolytic cleavage. Embedded throughout, we also highlight important knowledge gaps and avenues of future research. This article is part of a Special Issue entitled: Gap Junction Proteins edited by Jean Claude Herve. Highlights ? The discovery, topology and oligomerization of pannexin channels ? Cell and tissue distribution; dynamic expression during development and disease ? Post-translational modifications affecting pannexin trafficking and function
机译：摘要pannexins是一个3元蛋白质，形成脊椎动物的大孔离子和代谢物通道。 Pannexins对脊椎动物生物学的影响是错综复杂于表达的位置和何时表达的位置，以及曾经产生的修改。因此，本综述的目的是概述我们目前对转录和翻译后的帕南克斯的翻译后调节的理解。首先，我们简要概括了他们的发现和特征。接下来，我们描述转录调节的几个方面，包括细胞和组织特异性表达，对发展和疾病的动态表达，以及对所涉及的潜在分子机制的新见解。在此之后，我们深入研究贩运和渠道性质调节后翻译后修改，突出了对糖基化，磷酸化，S-亚硝基化和蛋白水解裂解的重要作用。嵌入综合下，我们还突出了未来研究的重要知识差距和途径。本文是题为的特殊问题的一部分：Jean Claude Herve编辑的Gap Junction蛋白。强调 ？ Pannexin通道的发现，拓扑和低聚吗？细胞和组织分布;发展与疾病过程中的动态表达？影响Pannexin贩运和功能的翻译后修改

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