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首页> 外文期刊>Biochimica et biophysica acta. Biomembranes >Modeling squid axon K + channel by a nucleation and growth kinetic mechanism
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Modeling squid axon K + channel by a nucleation and growth kinetic mechanism

机译：用成核和生长动力学机制建模鱿鱼轴k +通道

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Abstract A kinetic model accounting for all salient features of the K + channel of the squid giant axon, including the rising phase of the ON gating charge and the Cole-Moore effect, is provided. Upon accounting for a significant feature distinguishing K + , Na + and Ca 2+ channels from channel-forming peptides modeled in our previous 2016 BBA paper, the nucleation-and-growth kinetic model developed therein is extended to simulate ON ionic and gating currents of the K + channel of the squid giant axon at different depolarization potentials by the use of only two free parameters. K + channel opening is considered to proceed by progressive aggregation of single subunits, while they are moving their gating charge outward under depolarizing conditions within their tetrameric structure; K + channel closing proceeds in the opposite direction, by repolarization-induced disaggregation of subunits, accompanied by inward movement of their gating charge. Graphical abstract Display Omitted Highlights ? Channel opening proceeds by stepwise aggregation of single subunits within tetramer. ? K + channel closing proceeds by repolarization-induced disaggregation of subunits. ? Stepwise aggregation of single subunits moves their gating charge upward. ? Stepwise disaggregation of single subunits moves their gating charge downward. ? The model predicts salient features of K + channel behavior with two free parameters.
机译：摘要提供了鱿鱼巨型轴突的k +通道的所有显着特征的动力学模型，包括在包括对浇口电荷的上升阶段和柯氏摩尔效应。在考虑到我们以前的2016年BBA纸上建模的沟道形成肽的显着特征k +，Na +和Ca 2+通道时，其中产生的成核和生长动力学模型延长以模拟离子和门控电流鱿鱼巨型轴轴的K +通道通过仅使用两个自由参数的不同去极化电位。 k +通道开口被认为是通过单个亚基的渐进聚集进行，而它们在其四聚结构内的去极化条件下向外移动它们的门控; K +通道闭合在相反方向上进行，通过对亚基的解渗诱导的分解，伴随着它们的门控充电的内向运动。图形抽象显示省略了亮点？信道开头通过四分体内的单个亚基的逐步聚合进行。还K +通道关闭通过释放诱导的亚基分解进行进行。还单个亚基的逐步聚合向上移动它们的门控电荷。还单个亚基的逐步分解使其门控充电向下移动。还该模型预测了具有两个自由参数的K +信道行为的显着特征。

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