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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Protective effect of L-citrulline against acute gastric mucosal lesions induced by ischemia-reperfusion in rats.
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Protective effect of L-citrulline against acute gastric mucosal lesions induced by ischemia-reperfusion in rats.

机译：L-瓜氨酸对大鼠缺血再灌注诱导急性胃黏膜病变的保护作用。

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摘要

The present study investigated the protective effect of L-citrulline on gastric mucosal injury induced by ischemia-reperfusion (IR) in rats. Under anesthesia, the celiac artery was clamped for 30 min, and then the clamp was removed for 60 min reperfusion. Sixty minutes before ischemia, L-citrulline was administered intragastrically at doses of 300, 600, and 900 mg/kg. After the experiment, the stomachs were removed for biochemical and histological examinations. Pretreatment with L-citrulline (300, 600, and 900 mg/kg) significantly ameliorated the gastric damage caused by IR. Moreover, L-citrulline prevented the production of lipid peroxidation and inhibited the increase of myeloperoxidase activity. The elevation in total nitric oxide synthase (NOS) activity, inducible NOS activity, and inducible NOS protein expression as well as the decrease in constitutive NOS activity and gastric mucus level in the gastric mucosa induced by IR were significantly prevented. However, the protective effect mediated by L-citrulline was significantly antagonized by coadministration of L-nitroarginine methyl ester (10 mg/kg, s.c.). These results suggest that part of the mechanism of gastric protection by L-citrulline might be through inhibiting neutrophil infiltration and preserving gastric mucus synthesis and secretion in rats, functions that are closely related to the maintenance of constitutive NOS activity.
机译：本研究研究了L-Citrulline对大鼠缺血再灌注（IR）诱导的胃粘膜损伤的保护作用。在麻醉下，腹腔动脉夹紧30分钟，然后除去夹子60分钟再灌注。在缺血前六十分钟，L-瓜氨酸在300,600和900mg / kg的剂量下造成胃内施用。实验结束后，除去胃以进行生化和组织学检查。用L-瓜氨酸（300,600和900mg / kg）进行预处理显着改善了IR引起的胃损伤。此外，L-Citrulline预防脂质过氧化的产生并抑制髓过氧化物酶活性的增加。显着防止了IR诱导的胃粘膜中总氧化氮合酶（NOS）活性，诱导NOS活性和诱导的NOS蛋白表达中的胃癌的升高以及由IR诱导的胃粘膜中的胃粘膜中的减少。然而，通过L-Nitroarpinine甲酯（10mg / kg，s.c）的共同分析，由L-瓜氨酸介导的保护作用显着拮抗。这些结果表明，L-瓜育的胃保护机制的一部分可能是通过抑制中性粒细胞浸润和在大鼠中保留胃粘液合成和分泌，与维持组成型NOS活性密切相关的功能。

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