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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Vasoplegia in sepsis depends on the vascular system, vasopressor, and time-point: a comparative evaluation in vessels from rats subjected to the cecal ligation puncture model
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Vasoplegia in sepsis depends on the vascular system, vasopressor, and time-point: a comparative evaluation in vessels from rats subjected to the cecal ligation puncture model

机译：败血症的血管血管依赖于血管系统，血管加压器和时间点：患有盲肠结扎穿刺模型的大鼠血管的比较评价

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摘要

We evaluated the effects of phenylephrine, norepinephrine, angiotensin II, and vasopressin in mesenteric, renal, carotid, and tail arteries, and in perfused mesenteric vascular bed from rats subjected to the cecal ligation and puncture (CLP) model of sepsis. Phenylephrine and angiotensin II were less efficacious in mesenteric arteries from the CLP 6 h and CLP 18 h groups than in preparations from non-septic animals, but no differences were found for norepinephrine and vasopressin between the preparations. In renal arteries, none of the vasoconstrictors had impaired activity in the CLP groups. Nonetheless, carotid arteries from the CLP 18 h group presented reduced reactivity to all vasoconstrictors tested, but only phenylephrine and norepinephrine had their effects reduced in carotid arteries from the CLP 6 h group. Despite the reduced responsiveness to phenylephrine, tail arteries from septic rats were hyperreactive to vasopressin and norepinephrine at 6 h and 18 h after the CLP surgery, respectively. The mesenteric vascular bed from CLP groups was hyporeactive to phenylephrine, norepinephrine, and angiotensin II, but not to vasopressin. The vascular contractility in sepsis varies from the well-described refractoriness, to unaltered or even hyperresponsiveness to vasoconstrictors, depending on the vessel, the vasoactive agent, and the time period evaluated.
机译：我们评估了苯妥，去甲肾上腺素，血管紧张素II和血管加压素在肠系膜，肾，颈动脉和尾动中的影响，以及来自对败血症的盲肠结扎和穿刺（CLP）模型进行的大鼠灌注的肠系膜血管床。来自CLP 6 H和CLP 18 H组的肠系膜和血管紧张素II在肠系膜中的肠系膜中的效率低于非化脓性动物的制剂，但在制剂之间没有发现去甲肾上腺素和血管素的差异。在肾动脉中，血管收缩率没有血管收缩型在CLP组中受损。尽管如此，来自CLP 18 H组的颈动脉对所有测试的血管收缩剂的反应性降低，而且只有吩妥和去甲肾上腺素的作用，来自CLP 6 H组的颈动脉中的作用。尽管对苯妥的响应性降低，但分别在CLP手术后6小时和18小时，脓毒症大鼠的尾动术治疗对血管加压素和去甲肾上腺素过度反应。来自CLP基团的肠系膜血管床对苯妥碱，去甲肾上腺素和血管紧张素II有枯萎病，但不对瓦斯加压素。败血症中的血管收缩性因良好描述的耐火性而异，不妨碍甚至血管收缩剂的过度反应性，取决于血管，血管活性剂和评估的时间段。

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