...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >The effect of short-term oral treatment with omeprazole or pantoprazole on the function of polymorphonuclear neutrophils
【24h】

The effect of short-term oral treatment with omeprazole or pantoprazole on the function of polymorphonuclear neutrophils

机译：短期口服处理与奥美拉唑或泮托拉唑对多核核心粒细胞功能的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recent studies report an increased risk of enteric infections in patients treated with proton pump inhibitors (PPIs). Polymorphonuclear neutrophils (PMNs) play a key role in host response to bacterial infection. We evaluated the effect of omeprazole and pantoprazole treatment on the PMN function. Fifteen patients were treated with omeprazole 20 mg daily and 15 patients with pantoprazole 40 mg daily for 7 days. Treatment with omeprazole or pantoprazole had no effect on spontaneous nitroblue tetrazolium (NBT) test results. Significant increase in the percentage of phagocytes in the omeprazole group in stimulated NBT test (by 69%) was found. Treatment with omeprazole or pantoprazole had no effect on nitric oxide (NO) concentration in the PMN culture supernatant and serum, cyclic guanosine monophosphate concentration in the PMN culture supernatant and serum, as well as inducible nitric oxide synthase (iNOS) protein expression and p38 mitogen-activated protein kinase activity in PMNs. In conclusion, treatment with PPI has no effect on NO production and p38 mitogen-activated protein kinase activity in PMNs. Interestingly, short-term treatment with omeprazole but not with pantoprazole enhances PMN reactive oxygen species production.
机译：最近的研究报告了用质子泵抑制剂（PPI）治疗的患者肠道感染的风险增加。多环核嗜中性粒细胞（PMNS）在对细菌感染的宿主反应中发挥关键作用。我们评估了Omeprazole和PantoPrazole治疗对PMN功能的影响。每天用奥美拉唑20毫克治疗十五名患者，每天15例泮托拉唑每天服用7天。用奥美拉唑或泮托拉唑治疗对自发的硝基唑唑鎓（NBT）测试结果没有影响。发现刺激的NBT试验中奥美拉唑基团吞噬细胞百分比的显着增加（达69％）。用奥美拉唑或泮托拉唑处理对PMN培养上清液和血清中的一氧化氮（NO）浓度没有影响，在PMN培养上清液和血清中的循环鸟苷胺单磷酸盐浓度以及诱导的一氧化氮合酶（InOS）蛋白表达和P38丝裂原 - PMNS中的活化蛋白激酶活性。总之，用PPI治疗对PMN中没有生产和P38丝裂原活化蛋白激酶活性没有影响。有趣的是，与奥美拉唑的短期治疗，但没有泮托拉唑增强PMN反应性氧物种生产。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号