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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Does young age really put the heart at risk?
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Does young age really put the heart at risk?

机译：年轻的年龄真的让心脏有风险吗？

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摘要

Despite significant advances in the management and treatment of heart disease in children, there continue to be patients who have worse outcomes than might be expected. A number of risk factors that could be responsible have been identified. Evidence-based findings will be reviewed, including whether young age and (or) reduced body weight exacerbate these responses. For example, newborn children undergoing congenital cardiac surgery are known to have worse outcomes than older children. Evidence exists that newborn hearts do not tolerate ischemia as well as adult hearts, developing irreversible injury sooner and exhibiting at-risk metabolic profiles. As well, in response to the administration of heparin, elevations in free fatty acids occur during congenital heart surgery in children, which can have detrimental effects on the heart. Furthermore, myocardial energetic state has also been suggested to impact outcomes. Unfavourable energetic profiles were correlated to lower body weights in the same age healthy newborn piglet model. Newborn children suffering from congenital heart disease, with lower body weights, also had lower myocardial energetic state and this correlated with longer postoperative ventilatory support as well as a trend to longer intensive care unit stay. These findings imply that unfavourable myocardial metabolic profiles could contribute to postoperative complications.
机译：尽管儿童心脏病的管理和治疗方面取得了显着进展，但仍然存在比预期更糟糕的患者。已经确定了许多可能负责的风险因素。将审查基于证据的调查结果，包括年轻时和（或）减少体重加剧这些反应。例如，已知经历先天性心脏手术的新生儿患者比年龄较大的儿童更糟糕的结果。有证据存在，新生儿心脏不耐受缺血以及成年人心，越早发展不可逆的伤势并表现出风险的代谢谱。同样，响应于肝素的给药，在儿童的先天性心脏手术期间发生游离脂肪酸的升高，这可能对心脏有害影响。此外，也提出了心肌能量状态来影响结果。不利的活力曲线与同一年龄健康新生仔猪模型的低体重相关。患有先天性心脏病的新生儿儿童，体重较低，也具有较低的心肌能量状态，与术后术语通气支持较长的相关性以及更长的重症监护室住宿的趋势相关。这些发现意味着不利的心肌代谢型材可能有助于术后并发症。

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