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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Recombinant protein rMBP-NAP restricts tumor progression by triggering antitumor immunity in mouse metastatic lung cancer
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Recombinant protein rMBP-NAP restricts tumor progression by triggering antitumor immunity in mouse metastatic lung cancer

机译：重组蛋白RMBP-jap通过在小鼠转移性肺癌中引发抗肿瘤免疫来限制肿瘤进展

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摘要

Recombinant Helicobacter pylori neutrophil-activating protein fused with maltose-binding protein (rMBP-NAP), a potential TLR2 ligand, was reported to possess immunomodulatory effects on in situ tumors in our previous study. In the present work, we attempt to elucidate the effect of rMBP-NAP at the local immune modulation in B16-F10-induced metastatic lung cancer. Our results demonstrated that growth of B16-F10 melanoma metastases in the lung was significantly arrested after rMBP-NAP treatment, along with marked reduction in metastatic lung nodules and significant increase in survival. The treatment induced both local and systemic immune responses, which were associated with higher influx of CD4(+)/CD8(+) T cells and drove toward Th1-like and cytotoxic immune environment. Moreover, rMBP-NAP also showed significant anti-angiogenic activity by reducing vascularization in lung tumor sections. rMBP-NAP could induce antitumor immunity through activating Th1 cells and producing pro-inflammatory cytokines, which are responsible for the effective cytotoxic immune response against cancer progression. Our findings indicate that rMBP-NAP might be a novel antitumor therapeutic strategy.
机译：据报道，与麦芽糖结合蛋白（RMBP-NAP）融合的重组幽门螺杆菌偏离蛋白质融合了潜在的TLR2配体，以对我们之前的研究中原位肿瘤具有免疫调节作用。在本作的工作中，我们试图阐明在B16-F10诱导的转移性肺癌局部免疫调节时阐明人民币-NP-NAP的影响。我们的研究结果表明，在人民币-NAP治疗后，肺部B16-F10黑色素瘤转移的生长显着被捕，随着转移性肺结节的显着降低以及存活率的显着增加。该治疗诱导局部和全身免疫应答，其与CD4（+）/ CD8（+）T细胞的较高流入相关，并驱动朝向类似的细胞毒性免疫环境。此外，RMBP-NAP还通过在肺肿瘤切片中降低血管化而显示出显着的抗血管生成活性。通过激活Th1细胞并产生促炎细胞因子，可以诱导抗肿瘤免疫力，这些细胞因子负责对癌症进展的有效细胞毒性免疫应答。我们的调查结果表明，人民币休闲局部可能是一种新型抗肿瘤治疗策略。

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